Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
SUBSTITUTED MACROCYCLES USEFUL AS KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2020/228747
Kind Code:
A1
Abstract:
Provided are novel substituted macrocycles compounds, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds and compositions have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases mediated diseases and conditions.

Inventors:
ZHANG DAWEI (CN)
Application Number:
PCT/CN2020/090070
Publication Date:
November 19, 2020
Filing Date:
May 13, 2020
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
TELIGENE LTD (CN)
International Classes:
C07D498/18; A61K31/439; A61P35/00
Domestic Patent References:
WO2016026423A12016-02-25
WO2013132376A12013-09-12
WO2004076412A22004-09-10
WO2010068292A12010-06-17
WO2016026423A12016-02-25
WO2018137679A12018-08-02
Foreign References:
CN103373986A2013-10-30
Other References:
VIG, B. S. ET AL.: "Amino acids as promoieties in prodrug design and development", ADVANCED DRUG DELIVERY REVIEWS, vol. 65, no. 10, 15 October 2013 (2013-10-15), pages 1370 - 1385, XP028737354, DOI: 10.1016/j.addr.2012.10.001
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
T.W. GREENEP.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
L. FIESERM. FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
LIANGCHEN, EXPERT OPINION IN THERAPEUTIC PATENTS, vol. 11, no. 6, 2001, pages 981 - 986
M. BODANSZKYA. BODANSZKY: "The Practice of Peptide Synthesis", 1984, SPRINGER-VERLAG
J. SEYDEN-PENNE: "Reductions by the Alumino- and Borohydrides in Organic Synthesis", 1997, WILEY-VCH
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
See also references of EP 3844166A4
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
Download PDF: