Title:
SUBSTITUTED MALONAMIDES AND THEIR USE AS ANTIBACTERIAL DRUGS
Document Type and Number:
WIPO Patent Application WO/2017/028745
Kind Code:
A1
Abstract:
Disclosed are a series of malonamide derivatives having a chemical structure(I), their synthesis, and evaluation of their bioactivities against bacterial cell, bacterial-infected C.elegans and mice.
Inventors:
SHIAU CHUNG-WAI (CN)
CHIU HAO-CHIEH (CN)
CHIU HAO-CHIEH (CN)
Application Number:
PCT/CN2016/094855
Publication Date:
February 23, 2017
Filing Date:
August 12, 2016
Export Citation:
Assignee:
SHIAU CHUNG-WAI (CN)
CHIU HAO-CHIEH (CN)
CHIU HAO-CHIEH (CN)
International Classes:
C07C233/05; A61K31/16; A61K31/165; A61P31/04; C07C231/02; C07C233/06; C07C233/07
Domestic Patent References:
| WO2010028193A1 | 2010-03-11 | |||
| WO2002000650A2 | 2002-01-03 |
Foreign References:
| CN102503869A | 2012-06-20 | |||
| GB774802A | 1957-05-15 |
Other References:
WEN, JIA-CHEN ET AL.: "Synthesis and antitumor activity of S-hexyl(heptyl)substituted ethanethioate derivatives", ACTA PHARMACEUTICA SINICA, vol. 49, no. 3, 31 March 2014 (2014-03-31), pages 352 - 358, XP009508785, ISSN: 0513-4870
OELS, RICHARD ET AL.: "Reinvestigation of the Synthesis of 3-Dimethylallyl-4-hydroxy-2- quinolones.A Novel Route to Tetracyclic Heteroaromatic Compounds", J.C.S.PERKIRC I, 1 January 1977 (1977-01-01), pages 2546 - 2551, XP055365157, ISSN: 0300-922X
KAPPE, THOMAS ET AL.: "Synthesis of Benzo-halogenated 4-Hydroxy-2(1H)-quinolones", J.HETEROCYCLIC CHEM., vol. 25, 30 June 1988 (1988-06-30), pages 857 - 862, XP055365159, ISSN: 0022-152X
DAUBINET, ANDRÊ ET AL.: "DESIGNER LIGANDS. VII.THERMAL AND MILKUWAVE- ASSISTED SYNTHESIS OF SILVER(I)-SELECTIVE LIGANDS", SYNTHETIC COMMUNICATIONS, vol. 32, no. 20, 31 December 2002 (2002-12-31), pages 3207 - 3217, XP055515123, ISSN: 0039-7911
DAUBINET, ANDRÊ ET AL.: "DESIGNER LIGANDS.VIII.THERMAL AND MICROWAVE- ASSISTED SYNTHESIS OF SILVERS-SELECTIVE LIGANDS", SYNTHETIC COMMUNICATIONS, vol. 32, no. 20, 31 December 2002 (2002-12-31), XP055515123, ISSN: 0039-7911
CHANG HAN-CHU ET AL.: "In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA", J.ANTIMICROB CHEMOTHER, vol. 71, no. 2, 8 November 2015 (2015-11-08), pages 449 - 459, XP002760421, ISSN: 0305-7453
BLOCK ET AL.: "DEVELOPMENTS IN INDUSTRIAL MICROBIOLOGY", vol. 9, 1968, ELSEVIER SCIENCE BV, article "Antibacterial and antifungal activity of kepone derivatives", pages: 430 - 436
OELS, RICHARD ET AL.: "Reinvestigation of the Synthesis of 3-Dimethylallyl-4-hydroxy-2- quinolones.A Novel Route to Tetracyclic Heteroaromatic Compounds", J.C.S.PERKIRC I, 1 January 1977 (1977-01-01), pages 2546 - 2551, XP055365157, ISSN: 0300-922X
KAPPE, THOMAS ET AL.: "Synthesis of Benzo-halogenated 4-Hydroxy-2(1H)-quinolones", J.HETEROCYCLIC CHEM., vol. 25, 30 June 1988 (1988-06-30), pages 857 - 862, XP055365159, ISSN: 0022-152X
DAUBINET, ANDRÊ ET AL.: "DESIGNER LIGANDS. VII.THERMAL AND MILKUWAVE- ASSISTED SYNTHESIS OF SILVER(I)-SELECTIVE LIGANDS", SYNTHETIC COMMUNICATIONS, vol. 32, no. 20, 31 December 2002 (2002-12-31), pages 3207 - 3217, XP055515123, ISSN: 0039-7911
DAUBINET, ANDRÊ ET AL.: "DESIGNER LIGANDS.VIII.THERMAL AND MICROWAVE- ASSISTED SYNTHESIS OF SILVERS-SELECTIVE LIGANDS", SYNTHETIC COMMUNICATIONS, vol. 32, no. 20, 31 December 2002 (2002-12-31), XP055515123, ISSN: 0039-7911
CHANG HAN-CHU ET AL.: "In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA", J.ANTIMICROB CHEMOTHER, vol. 71, no. 2, 8 November 2015 (2015-11-08), pages 449 - 459, XP002760421, ISSN: 0305-7453
BLOCK ET AL.: "DEVELOPMENTS IN INDUSTRIAL MICROBIOLOGY", vol. 9, 1968, ELSEVIER SCIENCE BV, article "Antibacterial and antifungal activity of kepone derivatives", pages: 430 - 436
Attorney, Agent or Firm:
WINGUAN PATENT AND TRADEMARK ATTORNEYS (CN)
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