Title:
SUBSTITUTED N-ARYL AMIDINES AS SELECTIVE D1 DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND CNS DISORDERS
Document Type and Number:
WIPO Patent Application WO2005063697
Kind Code:
A3
Abstract:
The present invention provides compounds, which, are novel antagonists for D1 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1 receptor antagonists as well as methods of using them to treat CNS disorders, obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
Inventors:
BURNETT DUANE A (US)
WU WEN-LIAN (US)
DOMALSKI MARTIN S (US)
CAPLEN MARY ANN (US)
SPRING RICHARD (US)
LACHOWICZ JEAN E (US)
WU WEN-LIAN (US)
DOMALSKI MARTIN S (US)
CAPLEN MARY ANN (US)
SPRING RICHARD (US)
LACHOWICZ JEAN E (US)
Application Number:
PCT/US2004/042934
Publication Date:
December 22, 2005
Filing Date:
December 21, 2004
Export Citation:
Assignee:
SCHERING CORP (US)
BURNETT DUANE A (US)
WU WEN-LIAN (US)
DOMALSKI MARTIN S (US)
CAPLEN MARY ANN (US)
SPRING RICHARD (US)
LACHOWICZ JEAN E (US)
BURNETT DUANE A (US)
WU WEN-LIAN (US)
DOMALSKI MARTIN S (US)
CAPLEN MARY ANN (US)
SPRING RICHARD (US)
LACHOWICZ JEAN E (US)
International Classes:
A61K31/277; A61K31/405; A61K31/44; A61K31/445; A61K31/495; A61K45/06; C07C255/57; C07C257/14; C07C257/18; C07D211/28; C07D295/155; C07D295/205; (IPC1-7): C07C257/14; C07C257/18; C07D295/14
Domestic Patent References:
| WO2001098262A1 | 2001-12-27 |
Other References:
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OKUBO, MASAO ET AL: "Aryliminodimagnesium reagents. Part XXIII. Efficient formation of some amidines by the reactions of aryliminodimagnesium with weakly electron-accepting benzonitrile, N,N-dimethylformamide and related compounds. Features of reactions governed by .sigma.-complexation", XP002343239, retrieved from STN Database accession no. 1994:8251
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ROBEV, STEFAN: "Synthesis of some halogenated aromatic N-aryl-substituted amidines", XP002343240, retrieved from STN Database accession no. 1969:67829
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ROBEV, STEFAN: "Role of substituents in the molecule of aromatic amidines on their radio protective properties for Escherichia coli suspensions irradiated with .gamma.-rays", XP002343241, retrieved from STN Database accession no. 1961:60077
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343249, Database accession no. BRN 22523; BRN 242966; BRN 253801
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343250, Database accession no. BRN 2125212
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343251, Database accession no. BRN 2854029
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343252, Database accession no. BRN 2100469
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343253, Database accession no. BRN 142067
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343254, Database accession no. BRN 171568
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343255, Database accession no. BRN 3316904
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ROBEV, STEFAN: "Synthesis of some halogenated aromatic N-aryl-substituted amidines", XP002343240, retrieved from STN Database accession no. 1969:67829
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ROBEV, STEFAN: "Role of substituents in the molecule of aromatic amidines on their radio protective properties for Escherichia coli suspensions irradiated with .gamma.-rays", XP002343241, retrieved from STN Database accession no. 1961:60077
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343249, Database accession no. BRN 22523; BRN 242966; BRN 253801
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343250, Database accession no. BRN 2125212
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343251, Database accession no. BRN 2854029
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343252, Database accession no. BRN 2100469
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343253, Database accession no. BRN 142067
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343254, Database accession no. BRN 171568
DATABASE BEILSTEIN Institut zur Foerderung der Chemischen Wissenschaften; XP002343255, Database accession no. BRN 3316904
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