Title:
SUBSTITUTED NITROGEN HETEROCYCLIC COMPOUND AND ANESTHETIC EFFECT THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/068943
Kind Code:
A1
Abstract:
Disclosed in the present invention are a substituted nitrogen heterocyclic compound and anesthetic action thereof. Specifically provided are a chemical compound as shown in formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a prodrug thereof, a metabolite thereof or a deuterated derivative thereof. The substituted nitrogen heterocyclic compound provided in the present application has good central nervous system inhibition effects, capable of generating sedative, hypnotic and/or general anesthetic effects, and capable of controlling status epilepticus; said substituted nitrogen heterocyclic compound is also characterized by rapid onset of action and rapid recovery, while maintaining positive anesthetic activity; in addition, said substituted nitrogen heterocyclic compound has almost no inhibitory effect on adrenocortical function, low side effects, and resolves technical difficulties in the art. The present invention provides a new selection for clinical screening and/or preparation of sedative, hypnotic and/or general anesthetic drugs and drugs controlling status epilepticus.
Inventors:
LIU JIN (CN)
ZHANG WENSHENG (CN)
MA HAIJUN (CN)
WANG CHANGHUA (CN)
XIE ZHENBIAO (CN)
ZHANG WENSHENG (CN)
MA HAIJUN (CN)
WANG CHANGHUA (CN)
XIE ZHENBIAO (CN)
Application Number:
PCT/CN2020/120218
Publication Date:
April 15, 2021
Filing Date:
October 10, 2020
Export Citation:
Assignee:
CHENGDU MFS PHARMA CO LTD (CN)
International Classes:
A61K31/415; C07D231/14; A61K31/4155; A61P23/00; A61P25/08; A61P25/20; C07D249/04; C07D405/12; C07D409/12
Domestic Patent References:
| WO2017059827A1 | 2017-04-13 |
Foreign References:
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Other References:
LADI ENA, EVERETT CHRISTINE, STIVALA CRAIG E., DANIELS BLAKE E., DURK MATTHEW R., HARRIS SETH F., HUESTIS MALCOLM P., PURKEY HANS : "Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 15, 8 August 2019 (2019-08-08), US, pages 7032 - 7041, XP055799930, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00509
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BR J ANAESTH, vol. 48, no. 3, 1976, pages 213 - 6
ARCH INT PHARMACODYN THER, vol. 214, no. 1, 1975, pages 92 - 132
ACAD EMERG MED, vol. 13, no. 4, 2006, pages 378 - 83
LANCET, vol. 1, no. 8339, 1983, pages 1434
CRIT CARE, vol. 11, no. 3, 2007, pages 145
ANESTHESIOLOGY, vol. 114, no. 3, 2011, pages 695 - 707
COCHRANE DATABASE SYST REV, vol. 1, 2015
KLIN WOCHENSCHR, vol. 62, no. 21, 1984, pages 1014 - 7
CRIT CARE MED, vol. 40, no. 11, 2012, pages 2945 - 53
ANESTH ANALG, vol. 117, no. 6, 2013, pages 1329 - 37
ENGL J MED, vol. 310, no. 22, 1984, pages 1415 - 21
J CLIN ENDOCRINOL METAB, vol. 59, no. 6, 1984, pages 1143 - 7
J COMPUTE AIDED MOL DES, vol. 21, no. 8, 2007, pages 455 - 71
ANESTHESIOLOGY., vol. 125, no. 5, 2016, pages 943 - 951
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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