Title:
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/031818
Kind Code:
A3
Abstract:
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.
Inventors:
WANG GUANGYI (US)
BEIGELMAN LEONID (US)
DEVAL JEROME (US)
JEKLE CHRISTIAN ANDREAS (US)
BEIGELMAN LEONID (US)
DEVAL JEROME (US)
JEKLE CHRISTIAN ANDREAS (US)
Application Number:
PCT/US2017/046366
Publication Date:
May 11, 2018
Filing Date:
August 10, 2017
Export Citation:
Assignee:
ALIOS BIOPHARMA INC (US)
International Classes:
C07H19/16; A61K31/706; A61K31/7064; A61K31/7076; A61K31/708; A61P31/12; A61P31/14; A61P31/16; C07H19/14; C07H19/167; C07H19/20; C07H19/23
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LOREDANA CAPPELLACCI ET AL: "Synthesis, Biological Evaluation, and Molecular Modeling of Ribose-Modified Adenosine Analogues as Adenosine Receptor Agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 5, 1 March 2005 (2005-03-01), pages 1550 - 1562, XP055418246, ISSN: 0022-2623, DOI: 10.1021/jm049408n
Y.-L. CHEN ET AL: "Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, no. 8, 1 August 2010 (2010-08-01), pages 3255 - 3261, XP055462961, ISSN: 0066-4804, DOI: 10.1128/AAC.00397-10
LONGHU ZHOU ET AL: "-2'- C -Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 8, 7 April 2015 (2015-04-07), pages 3445 - 3458, XP055463795, ISSN: 0022-2623, DOI: 10.1021/jm501874e
EDWARD M. TYNDALL ET AL: "Prodrugs of imidazotriazine and pyrrolotriazine C-nucleosides can increase anti-HCV activity and enhance nucleotide triphosphate concentrations in vitro", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 4, 1 February 2015 (2015-02-01), AMSTERDAM, NL, pages 869 - 873, XP055418245, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2014.12.069
LOREDANA CAPPELLACCI ET AL: "Synthesis, Biological Evaluation, and Molecular Modeling of Ribose-Modified Adenosine Analogues as Adenosine Receptor Agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 5, 1 March 2005 (2005-03-01), pages 1550 - 1562, XP055418246, ISSN: 0022-2623, DOI: 10.1021/jm049408n
Y.-L. CHEN ET AL: "Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, no. 8, 1 August 2010 (2010-08-01), pages 3255 - 3261, XP055462961, ISSN: 0066-4804, DOI: 10.1128/AAC.00397-10
LONGHU ZHOU ET AL: "-2'- C -Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 8, 7 April 2015 (2015-04-07), pages 3445 - 3458, XP055463795, ISSN: 0022-2623, DOI: 10.1021/jm501874e
Attorney, Agent or Firm:
SHIRTZ, Joseph F. et al. (US)
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