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Title:
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/031818
Kind Code:
A3
Abstract:
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.

Inventors:
WANG GUANGYI (US)
BEIGELMAN LEONID (US)
DEVAL JEROME (US)
JEKLE CHRISTIAN ANDREAS (US)
Application Number:
US2017/046366
Publication Date:
May 11, 2018
Filing Date:
August 10, 2017
Export Citation:
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Assignee:
ALIOS BIOPHARMA INC (US)
International Classes:
C07H19/16; A61K31/706; A61K31/7064; A61K31/7076; A61K31/708; A61P31/12; A61P31/14; A61P31/16; C07H19/14; C07H19/167; C07H19/20; C07H19/23
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Other References:
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LONGHU ZHOU ET AL: "-2'- C -Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 8, 7 April 2015 (2015-04-07), pages 3445 - 3458, XP055463795, ISSN: 0022-2623, DOI: 10.1021/jm501874e
Attorney, Agent or Firm:
SHIRTZ, Joseph F. et al. (One Johnson & Johnson PlazaNew Brunswick, New Jersey, US)
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