SUBSTITUTED PHENYLAZOLE DERIVATIVE - DAIICHI SANKYO CO LTD

Title:

SUBSTITUTED PHENYLAZOLE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2013/108800

Kind Code:

A1

Abstract:

Provided are: a compound having an excellent hypoglycemic activity and an excellent protective activity for a β cell or the pancreas, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition having an excellent therapeutic effect and/or an excellent prophylactic effect on type-1 diabetes, type-2 diabetes and the like in which the increase in blood glucose level is induced by abnormal glucose metabolism. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

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Inventors:

YAMANOI SHIGEO (JP)
NAMIKI HIDENORI (JP)
OCHIAI YUICHI (JP)
HOSHINO MADOKA (JP)
MATSUMOTO KOJI (JP)

Application Number:

PCT/JP2013/050710

Publication Date:

July 25, 2013

Filing Date:

January 17, 2013

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Assignee:

DAIICHI SANKYO CO LTD (JP)

International Classes:

C07D249/06; A61K31/41; A61K31/4192; A61K31/421; A61K31/4245; A61K31/426; A61K31/427; A61K31/4439; A61P1/18; A61P3/00; A61P3/04; A61P3/10; A61P43/00; C07D257/04; C07D263/32; C07D271/06; C07D277/20; C07D277/30; C07D401/12; C07D401/14; C07D403/12; C07D413/12; C07D417/12

Domestic Patent References:

WO2011016469A1	2011-02-10
WO2011016470A1	2011-02-10
WO2007039178A2	2007-04-12
WO2005115383A2	2005-12-08
WO2002046174A1	2002-06-13
WO2007116229A1	2007-10-18
WO2012050151A1	2012-04-19
WO2013018675A1	2013-02-07
WO2007116229A1	2007-10-18
WO2007003960A1	2007-01-11
WO2007003962A2	2007-01-11
WO2005061489A1	2005-07-07
WO2009051119A1	2009-04-23
WO2010119881A1	2010-10-21
WO2011016469A1	2011-02-10
WO2011016470A1	2011-02-10
WO2012050151A1	2012-04-19
WO2010115751A2	2010-10-14

Other References:

POVL KROGSGAARD-LARSEN ET AL.: "A Textbook of Drug Design and Development", 1996, HARWOOD ACADEMIC PUBLISHERS, pages: 351 - 385
BIOORG. MED. CHEM., vol. 17, 2009, pages 7042 - 7051
J. MED. CHEM., vol. 52, 2009, pages 5950 - 5966
J. ORG. CHEM., vol. 70, 2005, pages 6346 - 6352
JUNKO OGAWA ET AL., LIFE SCIENCES, vol. 65, no. 12, 1999, pages 1287 - 1296
See also references of EP 2805941A4

Attorney, Agent or Firm:

ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)

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