Title:
SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/092201
Kind Code:
A1
Abstract:
Novel substituted phenylpropionic acid derivatives of the general formula (1), which bind to human peroxisome proliferator activated receptor $g(a) (PPAR$g(a)) as ligand to activate the receptor and thereby exhibit a potent lipid-decreasing effect; and use thereof as drugs: (1) wherein R?1¿ is lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, optionally substituted phenyl, optionally substituted phenoxy, or optionally substituted benzyloxy; R?2¿ is hydrogen, lower alkyl, or lower alkoxy; R?3¿ is lower alkoxy; and A is -CH¿2?CONH-, -NHCOCH¿2?-, -CH¿2?CH¿2?CO-, CH¿2?CH¿2?CH¿2?-, -CH¿2?CH¿2?O-, -CONHCH¿2?-, -CH¿2?NHCH¿2?-, -COCH¿2?O-, -OCH¿2?CO-, -COCH¿2?NH-, or NHCH¿2?CO-.
Inventors:
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
TAKAHASHI YUKIE (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOUJI (JP)
SUZUKI MASAHIRO (JP)
NOMURA MASAHIRO (JP)
TAKAHASHI YUKIE (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOUJI (JP)
SUZUKI MASAHIRO (JP)
Application Number:
PCT/JP2001/004385
Publication Date:
December 06, 2001
Filing Date:
May 25, 2001
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
TAKAHASHI YUKIE (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOUJI (JP)
SUZUKI MASAHIRO (JP)
MIYACHI HIROYUKI (JP)
NOMURA MASAHIRO (JP)
TAKAHASHI YUKIE (JP)
TANASE TAKAHIRO (JP)
MURAKAMI KOUJI (JP)
SUZUKI MASAHIRO (JP)
International Classes:
A61P3/06; A61P9/10; A61P43/00; C07C59/68; C07C69/734; C07C69/738; C07C229/34; C07C233/51; C07C233/55; C07C233/87; C07C235/34; C07C235/38; C07C235/52; C07C251/48; C07C323/56; (IPC1-7): C07C69/734; C07C69/738; C07C229/34; C07C233/55; C07C233/81; C07C235/44; C07C235/78; A61K31/192; A61P43/00; A61P3/06; A61P9/10
Domestic Patent References:
| WO1997036862A1 | 1997-10-09 | |||
| WO2000075103A1 | 2000-12-14 | |||
| WO2001025181A1 | 2001-04-12 |
Other References:
ZHANG JUAN ET AL.: "Polyphosphoric acid catalyzed conversion of 3-(methoxyphenyl) propionic acids to derivatives of (3.3) metacyclophane-1, 10-diones and 1-indanones", J. ORG. CHEM., vol. 58, no. 3, 1993, pages 556 - 559, XP002945092
Attorney, Agent or Firm:
Minoura, Kiyoshi (Kudankita 3-chome Chiyoda-ku Tokyo, JP)
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