Title:
SUBSTITUTED PROPANAMIDE DERIVATIVES, PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/009389
Kind Code:
A3
Abstract:
The present invention provides compounds of formula (I), the preparation thereof
and their use as peroxisome proliferator activated receptor-γ (PPAR-γ)
agonist in the treatment of diabetes and diabetic complications.
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Inventors:
WANG MINGWEI (CN)
LIU QING (CN)
ZHOU CAIHONG (CN)
WU BIN (CN)
HUI XIN (CN)
LIU QING (CN)
ZHOU CAIHONG (CN)
WU BIN (CN)
HUI XIN (CN)
Application Number:
PCT/CN2006/001784
Publication Date:
April 19, 2007
Filing Date:
July 20, 2006
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
WANG MINGWEI (CN)
LIU QING (CN)
ZHOU CAIHONG (CN)
WU BIN (CN)
HUI XIN (CN)
WANG MINGWEI (CN)
LIU QING (CN)
ZHOU CAIHONG (CN)
WU BIN (CN)
HUI XIN (CN)
International Classes:
C07C235/34; A61K31/16; A61K31/265; A61K31/277; A61K31/341; A61K31/351; A61K31/381; A61K31/40; A61K31/421; A61K31/435; A61P5/50; C07C231/12; C07C235/30; C07C237/20; C07C255/32; C07C327/40; C07C333/04; C07D207/32; C07D213/04; C07D263/32; C07D307/34; C07D309/34
Domestic Patent References:
WO2004099150A2 | 2004-11-18 |
Foreign References:
GB1434090A | 1976-04-28 |
Other References:
SHIRAISHI T. ET AL.: "Specific Inhibitors of Tyrosine-Specific Protein Kinase. I. Synthesis and Inhibitory of alpha-Cyanocinnamamides", CHEM. PHARM. BULL, vol. 36, no. 3, 1988, pages 974 - 981
WELLS G. ET AL.: "Structural Studies on bioactive Compounds. 32. Oxidation of Tyrphostin Protein Tyrosine Kinase Inhibitors with Hypervalent Iodine Reagents", J. MED. CHEM., vol. 43, no. 8, 2000, pages 1550 - 1562, XP003010625
WELLS G. ET AL.: "Structural Studies on bioactive Compounds. 32. Oxidation of Tyrphostin Protein Tyrosine Kinase Inhibitors with Hypervalent Iodine Reagents", J. MED. CHEM., vol. 43, no. 8, 2000, pages 1550 - 1562, XP003010625
Attorney, Agent or Firm:
SHANGHAI KAIJI INTELLECTUAL PROPERTY AGENT CO., LTD. (188 Nandandong Road, Shanghai 0, CN)
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