Title:
SUBSTITUTED PROPIONYL DERIVATIVES AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2000/000458
Kind Code:
A1
Abstract:
Compounds represented by general formula (1) or salts thereof and drugs containing the same as the active ingredient. In formula (1), X?1¿ represents carboxy, etc.; Y?1¿ represents a single bond, etc.; at least one of A?1¿, A?2¿ and A?3¿ represents a group represented by the following general formula (2):-R?2¿-a?1¿-R?3¿-a?2¿$m(7) (wherein R?2¿ represents divalent C¿2-12? hydrocarbyl; R?3¿ represents divalent C¿2-12? hydrocarbyl, etc.; and a?1¿ and a?2¿ represent each a single bond, -N(R?4¿)-, etc.); and at least one of Q?1¿, Q?2¿ and Q?3¿ represents cyclic hydrocarbyl or a heterocycle while the remaining one(s) represent hydrogen, optionally esterified carboxy, hydrocarbyl or a heterocycle. Because of having a potent inhibitory effect on squalene synthase, these compounds are useful as preventives and/or remedies for hypercholesterolemia, hyperlipemia and arteriosclerosis.
Inventors:
USUI HIROYUKI (JP)
KAGECHIKA KATSUJI (JP)
NAGASHIMA HAJIME (JP)
NAGAMOCHI MASATOSHI (JP)
OHTA MASAHIRO (JP)
YOKOMIZO AKI (JP)
MOTOKI KAYOKO (JP)
KAGECHIKA KATSUJI (JP)
NAGASHIMA HAJIME (JP)
NAGAMOCHI MASATOSHI (JP)
OHTA MASAHIRO (JP)
YOKOMIZO AKI (JP)
MOTOKI KAYOKO (JP)
Application Number:
PCT/JP1999/003411
Publication Date:
January 06, 2000
Filing Date:
June 25, 1999
Export Citation:
Assignee:
DAIICHI SEIYAKU CO (JP)
USUI HIROYUKI (JP)
KAGECHIKA KATSUJI (JP)
NAGASHIMA HAJIME (JP)
NAGAMOCHI MASATOSHI (JP)
OHTA MASAHIRO (JP)
YOKOMIZO AKI (JP)
MOTOKI KAYOKO (JP)
USUI HIROYUKI (JP)
KAGECHIKA KATSUJI (JP)
NAGASHIMA HAJIME (JP)
NAGAMOCHI MASATOSHI (JP)
OHTA MASAHIRO (JP)
YOKOMIZO AKI (JP)
MOTOKI KAYOKO (JP)
International Classes:
A61K31/195; A61K31/215; A61K31/36; A61K31/365; A61K31/38; A61K31/40; A61K31/42; A61K31/425; A61K31/495; A61K31/535; C07C69/716; C07C69/734; C07C69/738; C07C235/06; C07C235/74; C07C237/22; C07C255/54; C07C259/06; C07C311/51; C07D207/16; C07D263/54; C07D277/64; C07D295/20; C07D317/54; C07D317/58; C07D317/66; C07D319/12; C07D333/54; C07F7/18; (IPC1-7): C07C69/716; A61K31/195; A61K31/215; A61K31/36; A61K31/365; A61K31/38; A61K31/40; A61K31/42; A61K31/425; A61K31/495; A61K31/535; C07C69/734; C07C69/738; C07C235/06; C07C235/74; C07C237/22; C07C255/54; C07C259/06; C07C311/51; C07D207/16; C07D263/54; C07D277/64; C07D295/20; C07D317/54; C07D317/58; C07D317/66; C07D319/12; C07D333/54; C07F7/18
Domestic Patent References:
| WO1998029380A1 | 1998-07-09 |
Foreign References:
| GB2062622A | 1981-05-28 | |||
| JPH09509951A | 1997-10-07 | |||
| JPS5993069A | 1984-05-29 |
Attorney, Agent or Firm:
Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku Tokyo, JP)
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