Title:
SUBSTITUTED PYRAZINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/043077
Kind Code:
A1
Abstract:
(I) The present invention relates to a substituted pyrazine compound used as an SHP2 phosphatase inhibitor. Specifically, the present invention relates to the compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a tautomer, a polymorph, a solvate, an isotopically labeled compound, a metabolite, or a prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in the prevention and treatment of SHP2 phosphatase-related diseases.
Inventors:
CHEN SHOUJUN (CN)
YI LEI (CN)
SONG ZHIQUAN (CN)
WANG TAIJIN (CN)
SONG LIQIANG (CN)
WANG BO (CN)
LIU QIAN (CN)
CHEN HUIPING (CN)
YANG YU (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
XUE TONGTONG (CN)
WANG JINGYI (CN)
YI LEI (CN)
SONG ZHIQUAN (CN)
WANG TAIJIN (CN)
SONG LIQIANG (CN)
WANG BO (CN)
LIU QIAN (CN)
CHEN HUIPING (CN)
YANG YU (CN)
TIAN QIANG (CN)
SONG HONGMEI (CN)
XUE TONGTONG (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2020/112003
Publication Date:
March 11, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D401/04; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K31/538; A61P35/00; A61P35/02; C07D401/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/08; C07D471/18; C07D491/107
Domestic Patent References:
| WO2019075265A1 | 2019-04-18 |
Foreign References:
| CN109983001A | 2019-07-05 | |||
| CN105899493A | 2016-08-24 | |||
| CN105899491A | 2016-08-24 | |||
| CN109311848A | 2019-02-05 |
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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