Title:
SUBSTITUTED PYRAZOLE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2000/075131
Kind Code:
A1
Abstract:
Substituted pyrazole compounds of general formula (I) or salts thereof, which exhibit an excellent p38 MAP kinase inhibiting effect and are useful in the prevention or treatment of tumor necrosis factor $g(a)-related diseases, interleukin 1-related diseases, interleukin 6-related diseases, or cyclooxygenase II-related diseases wherein R?1¿ is -CH(OH)-CH(R?4¿)-(A)¿n?-Y, -CH¿2?-CH(R?4¿)-(A)¿n?-Y, -CO-B?1¿-A-Y, or the like (wherein A is lower alkylene; Y is aryl which may be substituted with, e.g., halogeno, or the like; R?4¿ is hydrogen or lower alkyl; B?1¿ is -CH(R?4¿)- or -N(R?4¿)-; and n is 0 or 1); R?2¿ is hydrogen, lower alkyl which may be substituted with hydroxyl or the like, or aralkyl; R?3¿ is phenyl which may be substituted with halogeno or the like, or pyridyl; and Q is pyridyl or quinolyl.
Inventors:
MINAMI NOBUYOSHI (JP)
SATO MICHITAKA (JP)
HASUMI KOICHI (JP)
YAMAMOTO NORIO (JP)
KEINO KATSUYUKI (JP)
MATSUI TERUAKI (JP)
KANADA ARIHIRO (JP)
OHTA SHUJI (JP)
SAITO TAKAHISA (JP)
SATO SHUICHIRO (JP)
ASAGARASU AKIRA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
SATO MICHITAKA (JP)
HASUMI KOICHI (JP)
YAMAMOTO NORIO (JP)
KEINO KATSUYUKI (JP)
MATSUI TERUAKI (JP)
KANADA ARIHIRO (JP)
OHTA SHUJI (JP)
SAITO TAKAHISA (JP)
SATO SHUICHIRO (JP)
ASAGARASU AKIRA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
Application Number:
PCT/JP2000/003547
Publication Date:
December 14, 2000
Filing Date:
June 01, 2000
Export Citation:
Assignee:
TEIKOKU HORMONE MFG CO LTD (JP)
MINAMI NOBUYOSHI (JP)
SATO MICHITAKA (JP)
HASUMI KOICHI (JP)
YAMAMOTO NORIO (JP)
KEINO KATSUYUKI (JP)
MATSUI TERUAKI (JP)
KANADA ARIHIRO (JP)
OHTA SHUJI (JP)
SAITO TAKAHISA (JP)
SATO SHUICHIRO (JP)
ASAGARASU AKIRA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
MINAMI NOBUYOSHI (JP)
SATO MICHITAKA (JP)
HASUMI KOICHI (JP)
YAMAMOTO NORIO (JP)
KEINO KATSUYUKI (JP)
MATSUI TERUAKI (JP)
KANADA ARIHIRO (JP)
OHTA SHUJI (JP)
SAITO TAKAHISA (JP)
SATO SHUICHIRO (JP)
ASAGARASU AKIRA (JP)
DOI SATOSHI (JP)
KOBAYASHI MOTOHIRO (JP)
SATO JUN (JP)
ASANO HAJIME (JP)
International Classes:
A61K31/4439; A61K31/4709; A61K31/4725; A61P11/06; A61P19/02; A61P21/00; A61P29/00; A61P31/18; A61P43/00; C07D401/04; C07D401/14; C07D405/14; C07D521/00; (IPC1-7): C07D401/04; C07D401/14; C07D405/14; A61K31/4439; A61K31/4709; A61K31/4725; A61K31/506; A61P29/00; A61P19/02; A61P21/00; A61P31/18; A61P11/06; A61P43/00
Domestic Patent References:
| WO1996003385A1 | 1996-02-08 | |||
| WO1995031451A1 | 1995-11-23 | |||
| WO1998052940A1 | 1998-11-26 | |||
| WO2000031063A1 | 2000-06-02 |
Other References:
See also references of EP 1188754A4
Attorney, Agent or Firm:
Odajima, Heikichi (Akasaka 1-chome Minato-ku Tokyo, JP)
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