Title:
SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUND, COMPOSITION CONTAINING THE SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/114388
Kind Code:
A1
Abstract:
The present disclosure provides a substituted pyrazolo[1,5-a]pyridine compound, composition containing same and use thereof. The substituted pyrazolo[1,5-a]pyridine compound is a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystalline form, pharmaceutically acceptable salt, hydrate, or solvate thereof. The compound of the present invention and composition thereof are useful for treating RET kinase-mediated diseases or conditions and have more excellent pharmacokinetic properties.
Inventors:
WANG YIHAN (CN)
REN XINGYE (CN)
REN XINGYE (CN)
Application Number:
PCT/CN2019/122674
Publication Date:
June 11, 2020
Filing Date:
December 03, 2019
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
A61K31/437; C07D471/04; A61P35/00
Domestic Patent References:
| WO2018071447A1 | 2018-04-19 | |||
| WO2017011776A1 | 2017-01-19 | |||
| WO2018071447A1 | 2018-04-19 |
Foreign References:
| CN108349969A | 2018-07-31 | |||
| US5376645A | 1994-12-27 |
Other References:
BERGE ET AL.: "pharmaceutically acceptable salts", J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
T. HIGUCHIV. STELLA: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Prodrugs as Novel Delivery Systems, A.C.S. Symposium Series"
D. FLEISHERS. RAMONH. BARBRA: "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", ADVANCED DRUG DELIVERY REVIEWS, vol. 19, no. 2, 1996, pages 115 - 130
WUTSGREENE: "Protective Groups in Organic Synthesis", 2006, JOHN WILEY & SONS
JEAN JACQUESANDRE COLLETSAMUEL H. WILEN: "Enantiomers, Racemates and Resolutions", 1981, JOHN WILEY AND SONS, INC.
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
NATURE REVIEWS CANCER, vol. 14, 2014, pages 173 - 186
T. HIGUCHIV. STELLA: "Bioreversible Carriers in Drug Design", vol. 14, 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS, article "Prodrugs as Novel Delivery Systems, A.C.S. Symposium Series"
D. FLEISHERS. RAMONH. BARBRA: "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", ADVANCED DRUG DELIVERY REVIEWS, vol. 19, no. 2, 1996, pages 115 - 130
WUTSGREENE: "Protective Groups in Organic Synthesis", 2006, JOHN WILEY & SONS
JEAN JACQUESANDRE COLLETSAMUEL H. WILEN: "Enantiomers, Racemates and Resolutions", 1981, JOHN WILEY AND SONS, INC.
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY
NATURE REVIEWS CANCER, vol. 14, 2014, pages 173 - 186
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