Title:
SUBSTITUTED PYRAZOLOPYRIMIDINES USEFUL AS KINASES INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2019/029629
Kind Code:
A1
Abstract:
Disclosed are novel pyrzaolopyrimidines of Formula (I), their derivatives, pharmaceutically acceptable salts, solvates and hydrates thereof. The compounds have protein kinases inhibitory activities and are expected to be useful for the treatment of protein kinases mediated diseases and conditions.
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Inventors:
ZHANG DAWEI (CN)
Application Number:
PCT/CN2018/099652
Publication Date:
February 14, 2019
Filing Date:
August 09, 2018
Export Citation:
Assignee:
TELIGENE LTD (CN)
International Classes:
C07D471/04; A61K31/519; A61P35/00
Domestic Patent References:
| WO2010048314A1 | 2010-04-29 | |||
| WO2010033941A1 | 2010-03-25 | |||
| WO2011006074A1 | 2011-01-13 | |||
| WO2008037477A1 | 2008-04-03 | |||
| WO2008058126A2 | 2008-05-15 | |||
| WO2007013673A1 | 2007-02-01 | |||
| WO2007025540A2 | 2007-03-08 | |||
| WO2008052734A1 | 2008-05-08 | |||
| WO2021158413A1 | 2021-08-12 | |||
| WO2010048314A1 | 2010-04-29 |
Foreign References:
| USPP61650019P |
Other References:
BRODEUR, G. M., NAT. REV. CANCER, vol. 3, 2003, pages 203 - 216
KRUETTGEN ET AL., BRAIN PATHOLOGY, vol. 16, 2006, pages 304 - 310
DIONNE ET AL., CLIN. CANCER RES., vol. 4, no. 8, 1998, pages 1887 - 1898
DANG ET AL., J. GASTROENTEROL. HEPATOL., vol. 21, no. 5, 2006, pages 850 - 858
MARCHETTI ET AL., HUMAN MUTATION, vol. 29, no. 5, 2008, pages 609 - 616
BARDELLI, A., SCIENCE, vol. 300, 2003, pages 949
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
T.W. GREENEP.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
L. FIESERM. FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
LIANGCHEN, EXPERT OPINION IN THERAPEUTIC PATENTS, vol. 11, no. 6, 2001, pages 981 - 986
M. BODANSZKYA. BODANSZKY: "The Practice of Peptide Synthesis", 1984, SPRINGER-VERLAG
J. SEYDEN-PENNE: "Reductions by the Alumino- and Borohydrides in Organic Synthesis", 1997, WILEY-VCH
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
See also references of EP 3661935A4
KRUETTGEN ET AL., BRAIN PATHOLOGY, vol. 16, 2006, pages 304 - 310
DIONNE ET AL., CLIN. CANCER RES., vol. 4, no. 8, 1998, pages 1887 - 1898
DANG ET AL., J. GASTROENTEROL. HEPATOL., vol. 21, no. 5, 2006, pages 850 - 858
MARCHETTI ET AL., HUMAN MUTATION, vol. 29, no. 5, 2008, pages 609 - 616
BARDELLI, A., SCIENCE, vol. 300, 2003, pages 949
R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS
T.W. GREENEP.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS
L. FIESERM. FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS
LIANGCHEN, EXPERT OPINION IN THERAPEUTIC PATENTS, vol. 11, no. 6, 2001, pages 981 - 986
M. BODANSZKYA. BODANSZKY: "The Practice of Peptide Synthesis", 1984, SPRINGER-VERLAG
J. SEYDEN-PENNE: "Reductions by the Alumino- and Borohydrides in Organic Synthesis", 1997, WILEY-VCH
"Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS
See also references of EP 3661935A4
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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