Title:
SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY
Document Type and Number:
WIPO Patent Application WO2001019823
Kind Code:
A3
Abstract:
The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
Inventors:
RILEY DENNIS (US)
NEUMANN WILLIAM L (US)
HENKE SUSAN L (US)
LENNON PATRICK (US)
ASHTON KARL W (US)
SALVEMINI DANIELA (US)
SIKORSKI JAMES A (US)
FOBIAN YVETTE (US)
GRAPPERHAUS LANAHAN (US)
KUSTURIN CARRIE L (US)
NEUMANN WILLIAM L (US)
HENKE SUSAN L (US)
LENNON PATRICK (US)
ASHTON KARL W (US)
SALVEMINI DANIELA (US)
SIKORSKI JAMES A (US)
FOBIAN YVETTE (US)
GRAPPERHAUS LANAHAN (US)
KUSTURIN CARRIE L (US)
Application Number:
PCT/US2000/025154
Publication Date:
September 07, 2001
Filing Date:
September 14, 2000
Export Citation:
Assignee:
MONSANTO CO (US)
RILEY DENNIS (US)
NEUMANN WILLIAM L (US)
HENKE SUSAN L (US)
LENNON PATRICK (US)
ASHTON KARL W (US)
SALVEMINI DANIELA (US)
SIKORSKI JAMES A (US)
FOBIAN YVETTE (US)
GRAPPERHAUS LANAHAN (US)
KUSTURIN CARRIE L (US)
RILEY DENNIS (US)
NEUMANN WILLIAM L (US)
HENKE SUSAN L (US)
LENNON PATRICK (US)
ASHTON KARL W (US)
SALVEMINI DANIELA (US)
SIKORSKI JAMES A (US)
FOBIAN YVETTE (US)
GRAPPERHAUS LANAHAN (US)
KUSTURIN CARRIE L (US)
International Classes:
A61K31/555; A61P1/00; A61P1/04; A61P7/02; A61P9/02; A61P9/10; A61P9/12; A61P17/06; A61P19/02; A61P25/04; A61P25/36; A61P29/00; A61P35/00; A61P35/04; A61P37/06; A61P39/00; A61P39/06; B01J31/22; C07D471/00; C07D471/06; C07D471/08; C07F13/00; (IPC1-7): C07D471/08; C07D471/06; A61K31/555; A61P29/00
Domestic Patent References:
| WO1997033877A1 | 1997-09-18 |
Foreign References:
| EP0524161A1 | 1993-01-20 |
Other References:
RILEY, DENNIS P. ET AL: "Synthesis, Characterization, and Stability of Manganese(II) C-Substituted 1,4,7,10,13-Pentaazacyclopentadecane Complexes Exhibiting Superoxide Dismutase Activity", INORG. CHEM. (1996), 35(18), 5213-5231, XP000993139
DATABASE CAPLUS Chemical Abstracts Service; XP002167353
FERRAUDI, G.: "Photochemistry of high-spin iron(III) complexes of the macrocyclic ligands [15]pydieneN5 and [15]pyaneN5. An investigation of the charge-transfer processes", INORG. CHEM. (1980), 19(2), 438-44, 1980, XP002167351
RAKOWSKI, MARY C. ET AL: "Synthesis and characterization of transition metal complexes containing a pentadentate macrocyclic ligand", INORG. CHEM. (1975), 14(5), 1194-200, 1975, XP002167352
SALVEMINI D ET AL: "A NONPEPTIDYL MIMIC OF SUPEROXIDE DISMUTASE WITH THERAPEUTIC ACTIVITY IN RATS", SCIENCE,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,,US, vol. 286, 8 October 1999 (1999-10-08), pages 304 - 306, XP000971099, ISSN: 0036-8075
DATABASE CAPLUS Chemical Abstracts Service; XP002167353
FERRAUDI, G.: "Photochemistry of high-spin iron(III) complexes of the macrocyclic ligands [15]pydieneN5 and [15]pyaneN5. An investigation of the charge-transfer processes", INORG. CHEM. (1980), 19(2), 438-44, 1980, XP002167351
RAKOWSKI, MARY C. ET AL: "Synthesis and characterization of transition metal complexes containing a pentadentate macrocyclic ligand", INORG. CHEM. (1975), 14(5), 1194-200, 1975, XP002167352
SALVEMINI D ET AL: "A NONPEPTIDYL MIMIC OF SUPEROXIDE DISMUTASE WITH THERAPEUTIC ACTIVITY IN RATS", SCIENCE,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,,US, vol. 286, 8 October 1999 (1999-10-08), pages 304 - 306, XP000971099, ISSN: 0036-8075
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