SUBSTITUTED PYRIDOPYRIMIDINONE COMPOUND, COMPOSITION COMPRISING SAME, AND USE THEREOF

Title:

SUBSTITUTED PYRIDOPYRIMIDINONE COMPOUND, COMPOSITION COMPRISING SAME, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/202501

Kind Code:

A1

Abstract:

A substituted pyridopyrimidinone compound, a composition comprising same, and use thereof. The compound is a compound represented by formula (I) or a tautomer, a stereoisomer, a prodrug, a crystal form, a pharmaceutically acceptable salt, a hydrate, or a solvate thereof. The compound represented by formula (I) can be used as a survival of motor neuron 2 (SMN2) gene splicing regulator for the treatment of spinal muscular atrophy (SMA), and has high selectivity and good pharmacokinetic properties.

Inventors:

WANG YIHAN (CN)
ZHAO JIUYANG (CN)

Application Number:

PCT/CN2023/088563

Publication Date:

October 26, 2023

Filing Date:

April 17, 2023

Export Citation:

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Assignee:

SHENZHEN TARGETRX INC (CN)

International Classes:

A61K31/519; C07D519/00; A61P21/00; A61P25/28

Foreign References:

CN108289959A	2018-07-17
US20190315773A1	2019-10-17
CN106459092A	2017-02-22

Other References:

JIANG WEN-FENG , LI WEN-BAO: "Application of Deuteration in Drug Research", QILU PHARMACEUTICAL AFFAIRS, vol. 29, no. 11, 1 January 2010 (2010-01-01), pages 682 - 684, XP008173943, ISSN: 1672-7738

Attorney, Agent or Firm:

SHENZHEN TARGETRX, INC. (CN)

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