SUBSTITUTED PYRIMIDINE DERIVATIVE

WIPO Patent Application WO/2005/085212

A1

A novel pyrimidine derivative characterized by having a saturated 6-membered heterocyclic group (for example, substituted piperidino) at the 2-position, a substituted amino group at the 4-position and a cyclic group at one of the 5- and 6-positions, or its salt. Because of having an effect of controlling the function of CC chemokine receptor 4 (CCR4) and showing an excellent antiinflammatory effect, the above compound is useful as a preventive or a remedy for inflammatory diseases, allergic diseases, autoimmune diseases and so on in which, in particular, CCR4 or TARC and/or MDC participate.

KAWANO NORIYUKI (JP)
KOGANEMARU YOHEI (JP)
MASUDA NAOYUKI (JP)
KAIZAWA HIROYUKI (JP)
HAMAGUCHI WATARU (JP)
MIYAZAKI TAKAHIRO (JP)

PCT/JP2005/003535

September 15, 2005

March 02, 2005

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YAMANOUCHI PHARMA CO LTD (JP)
KAWANO NORIYUKI (JP)
KOGANEMARU YOHEI (JP)
MASUDA NAOYUKI (JP)
KAIZAWA HIROYUKI (JP)
HAMAGUCHI WATARU (JP)
MIYAZAKI TAKAHIRO (JP)

A61K31/506; A61K31/5377; A61P1/04; A61P3/10; A61P11/02; A61P13/10; A61P17/00; A61P19/02; A61P25/00; A61P27/14; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P37/08; C07D239/48; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D413/14; (IPC1-7): C07D239/48; A61K31/506; A61K31/5377; A61P1/04; A61P3/10; A61P11/02; A61P13/10; A61P17/00; A61P19/02; A61P25/00; A61P27/14; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P37/08; C07D401/12; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D413/14

WO2004074260A1

2004-09-02

JP2003500477A	2003-01-07
JPS5049288A	1975-05-01

Morita, Hiroshi c/o Astellas Pharma Inc. (Intellectual Property 3-11, Nihonbashi-Honcho, 2-chom, Chuo-ku Tokyo 11, JP)

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