Title:
SUBSTITUTED PYRIMIDINE-FUSED RING INHIBITOR, METHOD FOR PREPARING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/002373
Kind Code:
A1
Abstract:
The present invention relates to a substituted pyrimidine-fused ring inhibitor, a method for preparing same, and use thereof. Specifically, the compound of the present invention has a structure represented by formula (I). Further disclosed are a method for preparing the compound, and use of the compound as a KRAS mutation inhibitor. The compound has a good selective inhibition effect on KRAS mutation and has better pharmacodynamic and pharmacokinetic performance and lower toxic and side effects.
Inventors:
LV BINHUA (CN)
CUI DAWEI (CN)
CUI DAWEI (CN)
Application Number:
PCT/CN2023/105261
Publication Date:
January 04, 2024
Filing Date:
June 30, 2023
Export Citation:
Assignee:
SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
SHANGHAI ZELGEN PHARMA TECH CO LTD (CN)
International Classes:
C07D471/04; A61K31/4745; A61K31/505; A61K31/519; A61P35/00; C07D471/14; C07D487/04; C07D498/04; C07D519/00
Domestic Patent References:
| WO2022132200A1 | 2022-06-23 | |||
| WO2022133038A1 | 2022-06-23 | |||
| WO2023018812A1 | 2023-02-16 | |||
| WO2023020518A1 | 2023-02-23 | |||
| WO2023020519A1 | 2023-02-23 | |||
| WO2023020521A1 | 2023-02-23 | |||
| WO2023061294A1 | 2023-04-20 | |||
| WO2023097227A1 | 2023-06-01 |
Foreign References:
| CN113666923A | 2021-11-19 | |||
| CN112694475A | 2021-04-23 | |||
| CN112824410A | 2021-05-21 |
Other References:
DATABASE Registry CAS; 6 March 2023 (2023-03-06), ANONYMOUS : "2-Naphthalenol, 5-ethynyl-6-fluo ro-4-[8-fluoro-2-[[1-(4- morpholinylmethyl)cyclopr opyl]methoxy]-4-(2-oxa-6-az abicyclo[5.1.0]oct-6- yl)pyrido[4,3-d]pyrimidin-7- yl]-", XP093124685, retrieved from STN Database accession no. 2904565-86-0
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: