Title:
SUBSTITUTED PYRIMIDINE PIPERAZINE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/062662
Kind Code:
A1
Abstract:
Disclosed are a substituted pyrimidine piperazine compound of Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and a pharmaceutical composition comprising the compound thereof. The substituted pyrimidine piperazine compound and the pharmaceutical composition disclosed herein can be used to inhibit 5-hydroxytryptamine reuptake and/or activate the 5-HT 1A receptors. Also disclosed is a method of preparing these compounds and pharmaceutical compositions, and their use for the treatment of central nervous system dysfunction.
Inventors:
JIN CHUANFEI (CN)
ZHONG WENHE (CN)
LIANG HAIPING (CN)
ZHANG YINGJUN (CN)
ZHONG WENHE (CN)
LIANG HAIPING (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2018/106956
Publication Date:
April 04, 2019
Filing Date:
September 21, 2018
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
A61K31/506; C07D403/14; A61P21/00; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30
Domestic Patent References:
| WO2016192657A1 | 2016-12-08 | |||
| WO2015169180A1 | 2015-11-12 | |||
| WO2001049678A1 | 2001-07-12 |
Foreign References:
| CN104725363A | 2015-06-24 |
Other References:
JONATHAN SAVITZIRWIN LUCKIWAYNE C. DREVETS: "5-HTIA receptor function in major depressive disorder", PROG NEUROBIOL., vol. 88, no. 1, 2009, pages 17 - 31
BROMET EANDRADE LHHWANG I ET AL.: "Cross-national epidemiology of DSM ITl major depressive episode", BMC MED, vol. 9, 2011, pages 90, XP021105691, DOI: 10.1186/1741-7015-9-90
SARKO J: "Andidepressant, old and new. A review of their adverse effects and toxicity in overdose", EMERG MED CLIN NORTH AM, vol. 18, no. 4, 2000, pages 637 - 54
CELADA PPUIG MAMARGOS-BOSCH M ET AL.: "The therapeutic role of 5-HTiA and 5-HT2A receptors in depression", J PSYCHIATRY NEUROSCI, vol. 29, no. 4, 2004, pages 252 - 65
FEIGER, A, PSYCHOPHARMACOL. BULL, vol. 32, 1996, pages 659 - 65
DIMITRIOU, E, J. CLIN. PSYCHOPHARMACOL., vol. 18, 1998, pages 465 - 9
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
"Principles of Asymmetric Synthesis", 2012
ELIEL, E.L: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
"Chiral Separation Techniques: A Practical Approach", 2007, WILEY-VCH VERLAG GMBH & CO. KGAA, WEINHEIM
See also references of EP 3687989A4
BROMET EANDRADE LHHWANG I ET AL.: "Cross-national epidemiology of DSM ITl major depressive episode", BMC MED, vol. 9, 2011, pages 90, XP021105691, DOI: 10.1186/1741-7015-9-90
SARKO J: "Andidepressant, old and new. A review of their adverse effects and toxicity in overdose", EMERG MED CLIN NORTH AM, vol. 18, no. 4, 2000, pages 637 - 54
CELADA PPUIG MAMARGOS-BOSCH M ET AL.: "The therapeutic role of 5-HTiA and 5-HT2A receptors in depression", J PSYCHIATRY NEUROSCI, vol. 29, no. 4, 2004, pages 252 - 65
FEIGER, A, PSYCHOPHARMACOL. BULL, vol. 32, 1996, pages 659 - 65
DIMITRIOU, E, J. CLIN. PSYCHOPHARMACOL., vol. 18, 1998, pages 465 - 9
"McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
"Principles of Asymmetric Synthesis", 2012
ELIEL, E.L: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
"Chiral Separation Techniques: A Practical Approach", 2007, WILEY-VCH VERLAG GMBH & CO. KGAA, WEINHEIM
See also references of EP 3687989A4
Download PDF: