SUBSTITUTED PYRROLO [2, 3-D] PYRIDAZIN-4-ONES AND PYRAZOLO [3, 4-D] PYRIDAZIN-4-ONES AS PROTEIN KINASE INHIBITORS

Title:

SUBSTITUTED PYRROLO [2, 3-D] PYRIDAZIN-4-ONES AND PYRAZOLO [3, 4-D] PYRIDAZIN-4-ONES AS PROTEIN KINASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2017/219955

Kind Code:

A1

Abstract:

Provided are certain compounds or pharmaceutically acceptable salts thereof which can inhibit kinase activity of Bruton's tyrosine kinase (BTK) and may be useful for the treatment of diseases like cancer, immunological disease and inflammation.

Inventors:

ZHAO XINGDONG (CN)
ZHANG WEIPENG (CN)
CHEN ZHIFANG (CN)
CHEN LING (CN)
WANG XIANLONG (CN)
LI ZHIFU (CN)
TAN RUI (CN)
YANG LIJUN (CN)
TAN HAOHAN (CN)
LIU BIN (CN)
RAN KAI (CN)
ZOU ZONGYAO (CN)
LIN MIN (CN)
SUN JING (CN)
WANG WEIBO (US)

Application Number:

PCT/CN2017/089123

Publication Date:

December 28, 2017

Filing Date:

June 20, 2017

Export Citation:

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Assignee:

SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN)
CHONGQING FOCHON PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D487/04; A61K31/519; A61P35/00

Domestic Patent References:

WO2014113942A1	2014-07-31
WO2014113932A1	2014-07-31
WO2016112637A1	2016-07-21

Other References: