Title:
SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/025307
Kind Code:
A1
Abstract:
Provided are substituted tricyclic compounds as PARP inhibitors and the use thereof. The compounds are represented by Formula (I) as below, wherein, the ring Z, Z1, Z2, A1, A2, A3, L and Cy are defined herein. The compounds of Formula (I) are PARP inhibitors and thus are useful in the treatment of diseases, disorders and conditions, such as cancer, responsive to the inhibition of PARP activity. Provided are also a pharmaceutical composition comprising the compound of Formula (I) and the use of the compound of Formula (I) in the preparation of a medicament for the treatment or prevention of diseases or conditions responsive to the inhibition of PARP activity.
Inventors:
CAI SUI XIONG (CN)
TIAN YE EDWARD (CN)
WANG XIAOZHU (CN)
TIAN YE EDWARD (CN)
WANG XIAOZHU (CN)
Application Number:
PCT/CN2022/115259
Publication Date:
March 02, 2023
Filing Date:
August 26, 2022
Export Citation:
Assignee:
IMPACT THERAPEUTICS SHANGHAI INC (CN)
International Classes:
C07D491/048; A61K31/496; A61P35/00; A61P35/02; C07D471/00; C07D471/04; C07D491/052; C07D491/147; C07D495/04
Domestic Patent References:
| WO2011014681A1 | 2011-02-03 |
Foreign References:
| CN107849040A | 2018-03-27 | |||
| CN102341394A | 2012-02-01 | |||
| US20050171101A1 | 2005-08-04 | |||
| CN111629757A | 2020-09-04 |
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (CN)
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