SUBSTITUTED UREAS AND CARBAMATES

WIPO Patent Application WO2004050609

A8

The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

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PULLEY SHON R (US)
TUCKER JOHN A (US)

PCT/US2003/037998

July 21, 2005

November 26, 2003

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ELAN PHARMACEUTICAL INC (US)
PHARMACIA & UPJOHN CO LLC (US)
PULLEY SHON R (US)
TUCKER JOHN A (US)

A61P25/28; C07C271/20; C07C271/52; C07C275/24; C07C275/28; C07D213/40; C07D215/42; C07D277/28; C07D309/14; C07D311/68; C07D311/76; C07D317/72; C07D335/06; C07D405/04; C07D407/06; (IPC1-7): C07C271/20; C07C271/52; C07C275/26; C07C311/05; C07D311/68; A61K31/17; A61K31/325; A61K31/63; A61K31/353; A61P25/28

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