SUBSTITUTED UREAS - SANKYO CO

Title:

SUBSTITUTED UREAS

Document Type and Number:

WIPO Patent Application WO/2006/019020

Kind Code:

A1

Abstract:

Urea derivatives having excellent DGAT inhibiting activity or pharmacologically acceptable salts thereof, namely, urea derivatives represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R¹ is C_6-10 aryl which may be substituted with one member selected from group (a) of substituents and/or one to four members independently selected from group (b) of substituents, or the like; R² is C_6-10 aryl which may be substituted with one member selected from group (a) of substituents and/or one to four members independently selected from group (b) of substituents, or the like; R³ and R⁴ are each independently hydrogen or the like; A is C_2-4 alkylene wherein one of the methylene groups constituting the main chain may be replaced by vinylene, oxygen, sulfur, sulfinyl, or sulfonyl, or the like; Q is -N(Me)- or sulfur; T is =CH- or nitrogen; and U and V are each independently =CH- or the like.

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Inventors:

HAYAKAWA ICHIRO
YOSHIDA MASAO
SUGANO YUICHI
KURATA HITOSHI
TANIMOTO TATSUO
KARASAWA HIROSHI
KOHAMA TAKAFUMI
UTO YOSHIKAZU

Application Number:

PCT/JP2005/014633

Publication Date:

February 23, 2006

Filing Date:

August 10, 2005

Export Citation:

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Assignee:

SANKYO CO (JP)
HAYAKAWA ICHIRO
YOSHIDA MASAO
SUGANO YUICHI
KURATA HITOSHI
TANIMOTO TATSUO
KARASAWA HIROSHI
KOHAMA TAKAFUMI
UTO YOSHIKAZU

International Classes:

A61K31/4164; A61K31/4196; A61K31/422; A61K31/426; A61K31/433; A61K31/4439; A61P1/16; A61P11/00; A61P13/12; A61P15/00; A61P19/02; A61P19/06; A61P25/02; A61P27/02; A61P29/00; A61P3/04; A61P3/06; A61P3/10; A61P43/00; A61P9/10; A61P9/12; C07D233/64; C07D249/08; C07D249/12; C07D277/28; C07D285/12; C07D401/04; C07D401/06; C07D401/14; C07D403/06; C07D405/12; C07D409/12; C07D413/12; (IPC1-7): C07D233/64; A61K31/4164; A61K31/4196; A61K31/422; A61K31/426; A61K31/433; A61K31/4439; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/00; A61P19/02; A61P19/06; A61P25/02; A61P27/02; A61P29/00; A61P43/00; C07D249/08; C07D249/12; C07D277/28; C07D285/12; C07D401/04; C07D401/06; C07D401/14; C07D403/06; C07D405/12; C07D409/12; C07D413/12

Domestic Patent References:

WO2004007455A1	2004-01-22
WO2005044192A2	2005-05-19

Foreign References:

EP1375611A2	2004-01-02
JPH1149762A	1999-02-23
JPH0892224A	1996-04-09
JP2004067635A	2004-03-04
JP2005206492A	2005-08-04

Attorney, Agent or Firm:

Yaguchi, Toshiaki (2-58 Hiromachi 1-chom, Shinagawa-ku Tokyo 10, JP)

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