Title:
SUBSTRATE FOR ANALYZING LIQUID BIOPSY-DERIVED BIOMATERIAL, METHOD FOR MANUFACTURING SAME, AND ANALYSIS METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/203134
Kind Code:
A1
Abstract:
The present invention relates to a substrate for analyzing a liquid biopsy-derived biomaterial, a method for manufacturing same, and an analysis method using same. More specifically, a substrate having a surface that has deposited thereon hydrophobic parylene arranged with a well-shaped pattern for the injection of a liquid biopsy sample has been confirmed to exhibit improved analysis accuracy through very effective and stable injection, into the surface of an analysis substrate, of nanoliter-level trace amounts of liquid biopsy samples such as plasma and urine, and to be able to increase analysis time and efficiency by analyzing trace amounts of a plurality of samples at one time through the arrangement of several tens to hundreds of wells on the surface of the substrate. Therefore, the substrate having a surface on which hydrophobic parylene arranged with a well-shaped pattern is deposited can be provided as a substrate for analyzing a trace amount of a liquid biopsy-derived biomaterial, and the substrate for analyzing can be applied to a fast mass analysis method for trace amounts of liquid biopsy samples.
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Inventors:
KIM MIN SIK (KR)
LIM HEE JIN (KR)
LIM HEE JIN (KR)
Application Number:
PCT/KR2021/011721
Publication Date:
September 29, 2022
Filing Date:
September 01, 2021
Export Citation:
Assignee:
DAEGU GYEONGBUK INST SCIENCE & TECH (KR)
International Classes:
B01L3/00; G01N23/2258; G01N33/68
Foreign References:
| US20100323915A1 | 2010-12-23 | |||
| US20110195496A1 | 2011-08-11 | |||
| US6559474B1 | 2003-05-06 |
Other References:
YU JIACHAO, ZHOU YUFAN, ENGELHARD MARK, ZHANG YUCHEN, SON JIYOUNG, LIU SONGQIN, ZHU ZIHUA, YU XIAO-YING: "In situ molecular imaging of adsorbed protein films in water indicating hydrophobicity and hydrophilicity", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 December 2020 (2020-12-01), pages 1 - 8, XP055971062, DOI: 10.1038/s41598-020-60428-1
JEONG JI-SEON, KIM SOOK-KYUNG, PARK SANG-RYOUL: "Amino acid analysis of dried blood spots for diagnosis of phenylketonuria using capillary electrophoresis-mass spectrometry equipped with a sheathless electrospray ionization interface", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 405, no. 25, 1 October 2013 (2013-10-01), Berlin/Heidelberg, pages 8063 - 8072, XP055971248, ISSN: 1618-2642, DOI: 10.1007/s00216-013-6999-6
JEONG JI-SEON, KIM SOOK-KYUNG, PARK SANG-RYOUL: "Amino acid analysis of dried blood spots for diagnosis of phenylketonuria using capillary electrophoresis-mass spectrometry equipped with a sheathless electrospray ionization interface", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 405, no. 25, 1 October 2013 (2013-10-01), Berlin/Heidelberg, pages 8063 - 8072, XP055971248, ISSN: 1618-2642, DOI: 10.1007/s00216-013-6999-6
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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