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Title:
SUCROSE ESTER-TYPE CATIONIC GENE VECTOR AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2016/127543
Kind Code:
A1
Abstract:
Provided are a class of sucrose ester-type cationic lipoids and a preparation method therefor. A vector prepared by using the cationic lipoid can be used to deliver a nucleic acid. The sucrose ester-type cationic lipoid is prepared by using a chemical synthesis method, wherein the synthesis method is simple, and the product yield is relatively high. A composition, including a suspension, an emulsion, a micelle and a liposome and the like, can be prepared by mixing the sucrose ester-type cationic lipoid compound with a lipoid auxiliary. A sucrose ester-type cationic lipoid complex can be prepared by using the above-mentioned composition and a nucleic acid, which has advantages such as a simple preparation, a low toxicity and a high transfection efficiency, and is a novel and highly efficient gene vector.

Inventors:
ZHANG SHUBIAO (CN)
ZHI DEFU (CN)
CUI SHAOHUI (CN)
ZHAO YINAN (CN)
ZHOU QUAN (CN)
Application Number:
CN2015/082263
Publication Date:
August 18, 2016
Filing Date:
June 25, 2015
Export Citation:
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Assignee:
DALIAN NAT UNIV (CN)
International Classes:
C07H13/06; C07H1/00; C07J17/00; C12N15/63; C12N15/87; C12N15/88
Domestic Patent References:
WO2004104016A12004-12-02
WO2006016097A22006-02-16
Foreign References:
CN101560228A2009-10-21
CN102417527A2012-04-18
CN103553970A2014-02-05
CN1844402A2006-10-11
US20090074935A12009-03-19
Attorney, Agent or Firm:
DALIAN YITONG PATENT OFFICE(COMMON PARTNERSHIP) (CN)
大连一通专利代理事务所(普通合伙) (CN)
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