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Title:
SUCROSE ESTER-TYPE CATIONIC GENE VECTOR AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2016/127543
Kind Code:
A1
Abstract:
Provided are a class of sucrose ester-type cationic lipoids and a preparation method therefor. A vector prepared by using the cationic lipoid can be used to deliver a nucleic acid. The sucrose ester-type cationic lipoid is prepared by using a chemical synthesis method, wherein the synthesis method is simple, and the product yield is relatively high. A composition, including a suspension, an emulsion, a micelle and a liposome and the like, can be prepared by mixing the sucrose ester-type cationic lipoid compound with a lipoid auxiliary. A sucrose ester-type cationic lipoid complex can be prepared by using the above-mentioned composition and a nucleic acid, which has advantages such as a simple preparation, a low toxicity and a high transfection efficiency, and is a novel and highly efficient gene vector.

Inventors:
ZHANG, Shubiao (No. 18, Liaohe West Road Jinzhou New District, Dalian Liaoning 0, 116600, CN)
ZHI, Defu (No. 18, Liaohe West Road Jinzhou New District, Dalian Liaoning 0, 116600, CN)
CUI, Shaohui (No. 18, Liaohe West Road Jinzhou New District, Dalian Liaoning 0, 116600, CN)
ZHAO, Yinan (No. 18, Liaohe West Road Jinzhou New District, Dalian Liaoning 0, 116600, CN)
ZHOU, Quan (No. 18, Liaohe West Road Jinzhou New District, Dalian Liaoning 0, 116600, CN)
Application Number:
CN2015/082263
Publication Date:
August 18, 2016
Filing Date:
June 25, 2015
Export Citation:
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Assignee:
DALIAN NATIONALITIES UNIVERSITY (No. 18, Liaohe West Road Jinzhou New District, Dalian Liaoning 0, 116600, CN)
International Classes:
C07H13/06; C07H1/00; C07J17/00; C12N15/63; C12N15/87; C12N15/88
Domestic Patent References:
WO2004104016A12004-12-02
WO2006016097A22006-02-16
Foreign References:
CN101560228A2009-10-21
CN102417527A2012-04-18
CN103553970A2014-02-05
CN1844402A2006-10-11
US20090074935A12009-03-19
Attorney, Agent or Firm:
DALIAN YITONG PATENT OFFICE(COMMON PARTNERSHIP) (Room 218, No.246 Changchun Road, Xigang District, Dalian Liaoning 3, 116013, CN)
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