Title:
SUGAR-ADDED ENCLOMIPHENE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2018/026087
Kind Code:
A3
Abstract:
Compounds of chemical formula 1 or pharmaceutically acceptable salts thereof according to the present invention are sugar-added enclomiphene derivatives that improve bioavailability while maintaining antagonistic activity to estrogen receptor α (ERα), and can be advantageously used as prodrugs or alternative modified dosage forms that can treat estrogen receptor-related diseases, such as osteoporosis, menopausal vaginal atrophy, dyspareunia, gynecomastia, male secondary hypogonadism, non-insulin dependent diabetes, lipid dystrophy, infertility, male prostatic hyperplasia, prostate cancer, ovarian cancer, and breast cancer.
Inventors:
PARK JE WON (KR)
Application Number:
PCT/KR2017/004022
Publication Date:
August 09, 2018
Filing Date:
April 13, 2017
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07H15/18; A61K31/70
Domestic Patent References:
| WO2001027127A1 | 2001-04-19 | |||
| WO2009035652A1 | 2009-03-19 |
Foreign References:
| KR20010108719A | 2001-12-08 | |||
| KR20170011543A | 2017-02-02 |
Other References:
MCCAGUE, R.: "Metabolism of tamoxifen by isolated rat hepatocytes: Identification of the glucuronide of 4-hydroxytamoxifen", BIOCHEMICAL PHARMACOLOGY, 1 May 1990 (1990-05-01), pages 1459 - 1465, XP025521625
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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