Title:
SUGAR-LINKED POLYNUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2023/210233
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a technique for effectively exerting the activity of a polynucleotide in the brain. The problem is solved by a compound represented by general formula (1) [In the formula, Ms represents a monovalent group obtained by removing one atom or group from a monosaccharide. Lk represents a divalent group that is a linker. Pn represents a monovalent group obtained by removing one atom or group from a polynucleotide.], or a salt thereof, or solvates thereof.
Inventors:
KODAMA TETSUYA (JP)
MOAI YOSHIHIRO (JP)
MITSUMORI EIJI (JP)
KAMADA HARUHIKO (JP)
NAKAYAMA TAISUKE (JP)
MOAI YOSHIHIRO (JP)
MITSUMORI EIJI (JP)
KAMADA HARUHIKO (JP)
NAKAYAMA TAISUKE (JP)
Application Number:
PCT/JP2023/012164
Publication Date:
November 02, 2023
Filing Date:
March 27, 2023
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
A61K31/7088; C07H15/26; A61K31/7105; A61K31/711; A61K31/713; A61K47/54; A61P25/00; A61P43/00; C12N15/113
Domestic Patent References:
| WO2015075942A1 | 2015-05-28 |
Other References:
NISHIKAWA MAKIYA, YUKITAKE YOSHIOKA, MAKOTO NAGAOKA, KOSUKE KUSAMORI: "Development of Oligonucleotide Therapeutics: Tissue Distribution and Drug Delivery System", DDS. DRUG DELIVERY SYSTEM, vol. 36, no. 1, 25 January 2021 (2021-01-25), pages 40 - 50, XP093006747, DOI: 10.2745/dds.36.40
LIAO WENQING, AKAHIRA SAKIKO, HARA RINTARO IWATA, WADA TAKESHI, KUSAMORI KOSUKE, TAKAKURA YOSHINOBU, NISHIKAWA MAKIYA: "Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA", BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 43, no. 8, 1 August 2020 (2020-08-01), JP , pages 1188 - 1195, XP093105521, ISSN: 0918-6158, DOI: 10.1248/bpb.b20-00052
NAGATA TETSUYA; DWYER CHRISSA A.; YOSHIDA-TANAKA KIE; IHARA KENSUKE; OHYAGI MASAKI; KABURAGI HIDETOSHI; MIYATA HARUKA; EBIHARA SAT: "Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 39, no. 12, 12 August 2021 (2021-08-12), New York, pages 1529 - 1536, XP037639828, ISSN: 1087-0156, DOI: 10.1038/s41587-021-00972-x
KUWAHARA HIROYA, TAKANORI YOKOTA: "Efficient DDS that crosses the blood-brain barrier in response to changes in blood glucose concentration", DRUG DELIVERY SYSTEM, vol. 34, no. 5, 1 January 2019 (2019-01-01), pages 352 - 359, XP093105528, DOI: 10.2745/dds.34.352
TETSUYA KODAMA, YOSHIHIRO HYAKUSO, EIJI MIMORI, SHUICHI HIROAKI, RISA HYAKUSO, TATSUYA CHIKADA: "1P-19 Usefulness and cautionary points of post-synthetic modification of oligonucleotides by click", PROCEEDINGS OF THE 6TH ANNUAL MEETING OF THE NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN; JUNE 27TH TO 29TH, 2021, NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN, JP, vol. 6, 1 January 2021 (2021-01-01) - 29 June 2021 (2021-06-29), JP, pages 101, XP009550138
ANONYMOUS: "Practical Application of Five Types of Reagents Contributing to Nucleic Acid Therapeutics (RNA) Life Prolongation and Anticancer Activity - Manufacture/Sale Agreement for Nucleic Acid Therapeutic Study Reagent Executed with Kanto Kagaku - Streamlining R&D with Safe and Easy Post-Modification of RNA ", PRESS RELEASE OF TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, GIFU UNIVERSITY, 24 May 2016 (2016-05-24), XP093105533
LIAO WENQING, AKAHIRA SAKIKO, HARA RINTARO IWATA, WADA TAKESHI, KUSAMORI KOSUKE, TAKAKURA YOSHINOBU, NISHIKAWA MAKIYA: "Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA", BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 43, no. 8, 1 August 2020 (2020-08-01), JP , pages 1188 - 1195, XP093105521, ISSN: 0918-6158, DOI: 10.1248/bpb.b20-00052
NAGATA TETSUYA; DWYER CHRISSA A.; YOSHIDA-TANAKA KIE; IHARA KENSUKE; OHYAGI MASAKI; KABURAGI HIDETOSHI; MIYATA HARUKA; EBIHARA SAT: "Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 39, no. 12, 12 August 2021 (2021-08-12), New York, pages 1529 - 1536, XP037639828, ISSN: 1087-0156, DOI: 10.1038/s41587-021-00972-x
KUWAHARA HIROYA, TAKANORI YOKOTA: "Efficient DDS that crosses the blood-brain barrier in response to changes in blood glucose concentration", DRUG DELIVERY SYSTEM, vol. 34, no. 5, 1 January 2019 (2019-01-01), pages 352 - 359, XP093105528, DOI: 10.2745/dds.34.352
TETSUYA KODAMA, YOSHIHIRO HYAKUSO, EIJI MIMORI, SHUICHI HIROAKI, RISA HYAKUSO, TATSUYA CHIKADA: "1P-19 Usefulness and cautionary points of post-synthetic modification of oligonucleotides by click", PROCEEDINGS OF THE 6TH ANNUAL MEETING OF THE NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN; JUNE 27TH TO 29TH, 2021, NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN, JP, vol. 6, 1 January 2021 (2021-01-01) - 29 June 2021 (2021-06-29), JP, pages 101, XP009550138
ANONYMOUS: "Practical Application of Five Types of Reagents Contributing to Nucleic Acid Therapeutics (RNA) Life Prolongation and Anticancer Activity - Manufacture/Sale Agreement for Nucleic Acid Therapeutic Study Reagent Executed with Kanto Kagaku - Streamlining R&D with Safe and Easy Post-Modification of RNA ", PRESS RELEASE OF TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM, GIFU UNIVERSITY, 24 May 2016 (2016-05-24), XP093105533
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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