Title:
SUGAR RESPONSIVE GEL AND MEDICINE ADMINISTERING DEVICE
Document Type and Number:
WIPO Patent Application WO/2011/148941
Kind Code:
A1
Abstract:
Disclosed are a sugar responsive gel and a medicine administering device having a pKa more suitable for use in a body environment and capable of administering medicine more autonomously than before. A sugar responsive gel and an insulin administering device having a pKa more suitable for use in a body environment and capable of administering insulin more autonomously than before, wherein under a body condition of pKa of 7.4 or less and temperature of 35°C-40°C, when the glucose concentration increases insulin can be released from a gel body in response thereto, and when the glucose concentration decreases insulin release from the gel body can be suppressed.
Inventors:
MATSUMOTO AKIRA (JP)
ISHII TAKEHIKO (JP)
KATAOKA KAZUNORI (JP)
MIYAHARA YUJI (JP)
ISHII TAKEHIKO (JP)
KATAOKA KAZUNORI (JP)
MIYAHARA YUJI (JP)
Application Number:
PCT/JP2011/061869
Publication Date:
December 01, 2011
Filing Date:
May 24, 2011
Export Citation:
Assignee:
NAT INST FOR MATERIALS SCIENCE (JP)
MATSUMOTO AKIRA (JP)
ISHII TAKEHIKO (JP)
KATAOKA KAZUNORI (JP)
MIYAHARA YUJI (JP)
MATSUMOTO AKIRA (JP)
ISHII TAKEHIKO (JP)
KATAOKA KAZUNORI (JP)
MIYAHARA YUJI (JP)
International Classes:
A61K9/00; A61K47/32; A61K38/28; A61M1/36
Domestic Patent References:
| WO2011083711A1 | 2011-07-14 |
Foreign References:
| JPH11322761A | 1999-11-24 | |||
| JPS6187565A | 1986-05-02 | |||
| JP2006505305A | 2006-02-16 |
Other References:
KABILANA, K. ET AL.: "Holographic glucose sensors", BIOSENSORS AND BIOELECTRONICS, vol. 20, no. 8, 2005, pages 1602 - 1610, XP027619502
MATSUMOTO, A. ET AL.: "Glucose-Responsive Polymer Gel Bearing Phenylborate Derivative as a Glucose-Sensing Moiety Operating at the Physiological pH", BIOMACROMOLECULES, vol. 5, no. 3, 2004, pages 1038 - 1045, XP008159372
YAN, J. ET AL.: "The relationship among pKa, pH, and binding constants in the interactions between boronic acids and diols-it is not as simple as it appears", TETRAHEDRON, vol. 60, no. 49, 2004, pages 11205 - 11209, XP004617676
See also references of EP 2578234A4
MATSUMOTO, A. ET AL.: "Glucose-Responsive Polymer Gel Bearing Phenylborate Derivative as a Glucose-Sensing Moiety Operating at the Physiological pH", BIOMACROMOLECULES, vol. 5, no. 3, 2004, pages 1038 - 1045, XP008159372
YAN, J. ET AL.: "The relationship among pKa, pH, and binding constants in the interactions between boronic acids and diols-it is not as simple as it appears", TETRAHEDRON, vol. 60, no. 49, 2004, pages 11205 - 11209, XP004617676
See also references of EP 2578234A4
Attorney, Agent or Firm:
USHIKI, Mamoru (JP)
牛木 護 (JP)
牛木 護 (JP)
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Claims: