Title:
SULFAMIDE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISM
Document Type and Number:
WIPO Patent Application WO/2012/070114
Kind Code:
A1
Abstract:
The present invention provides, as a novel compound having NPY Y5 receptor antagonism, a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same.
In formula (I): R1 and R2 independently represent each hydrogen, substituted or unsubstituted alkyl,or the like, or R1 and R2 may form, together with the adjacent nitrogen atom, a substituted or unsubstituted nitrogen-containing aromatic heterocycle or a substituted or unsubstituted nitrogen-containing non-aromatic heterocycle; X represents an aromatic heterocycle or a non-aromatic heterocycle; R3s independently represent each substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl; R4s independently represent each halogen, cyano, or the like; R5 represents hydrogen, substituted or unsubstituted alkyl, etc.; m is an integer of 0-2; n is an integer of 0-5: Rs independently represent each halogen, oxo, or the like; and p is an integer of 0-2.
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Inventors:
OKUNO, Takayuki (12-4, Sagisu 5-chome, Fukushima-ku, Osaka-sh, Osaka 02, 〒5530002, JP)
奥野 隆行 (〒02 大阪府大阪市福島区鷺洲5丁目12番4号 塩野義製薬株式会社内 Osaka, 〒5530002, JP)
奥野 隆行 (〒02 大阪府大阪市福島区鷺洲5丁目12番4号 塩野義製薬株式会社内 Osaka, 〒5530002, JP)
Application Number:
JP2010/070876
Publication Date:
May 31, 2012
Filing Date:
November 24, 2010
Export Citation:
Assignee:
Shionogi & Co. Ltd. (1-8 Doshomachi 3-chome, Chuo-ku Osaka-sh, Osaka 45, 〒5410045, JP)
塩野義製薬株式会社 (〒45 大阪府大阪市中央区道修町3丁目1番8号 Osaka, 〒5410045, JP)
OKUNO, Takayuki (12-4, Sagisu 5-chome, Fukushima-ku, Osaka-sh, Osaka 02, 〒5530002, JP)
塩野義製薬株式会社 (〒45 大阪府大阪市中央区道修町3丁目1番8号 Osaka, 〒5410045, JP)
OKUNO, Takayuki (12-4, Sagisu 5-chome, Fukushima-ku, Osaka-sh, Osaka 02, 〒5530002, JP)
International Classes:
C07D207/335; A61K31/40; A61K31/404; A61K31/415; A61K31/4164; A61K31/4184; A61K31/4196; A61K31/437; A61K31/454; A61K31/4985; A61K31/519; A61K31/5377; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P9/04; A61P9/10; A61P9/12; A61P15/00; A61P25/08; A61P25/20; A61P25/24; A61P43/00; C07D207/34; C07D209/14; C07D231/12; C07D231/14; C07D231/16; C07D231/38; C07D233/64; C07D235/04; C07D249/08; C07D401/04; C07D403/04; C07D413/04; C07D413/12; C07D417/08; C07D471/04; C07D487/04
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (Shionogi & Co, Ltd. Intellectual Property Department 12-4, Sagisu 5-chome, Fukushima-ku, Osaka-sh, Osaka 02, 〒5530002, JP)
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Claims:
