Title:
SULFATED GALACTANS WITH ANTITHROMBOTIC ACTIVITY, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING OR PROPHYLAXIS OF ARTERIAL OR VENOUS THROMBOSIS, METHOD OF EXTRACTION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/137899
Kind Code:
A3
Abstract:
The present invention relates to low molecular weight sulfated galactans, obtained from algae, particularly genus Botryocladia, preferably species Botryocladia occidentallis, which have no effect on the factor XII activation of the clotting cascade, having antithrombotic heparinoid activity. The present invention also refers to a pharmaceutical composition comprising said sulfated galactans and the use thejreof, as heparin substitute, in the treatment or prophylaxis of arterial or venous thrombosis in humans and animals. Furthermore, the present invention provides a method of extraction of the said sulfated galactans.
More Like This:
Inventors:
MOURAO PAULO ANTONIO DE SOUZA (BR)
MELO FABIO RABELO (BR)
MELO FABIO RABELO (BR)
Application Number:
PCT/BR2009/000125
Publication Date:
December 02, 2010
Filing Date:
May 12, 2009
Export Citation:
Assignee:
DELTA DO PRATA SA (BR)
International Classes:
A61K31/737; C07H11/00
Other References:
FONSECA ET AL.: "Slight differences in sulfation of algal galactans account for differences in their anticoagulant and venous antithrombotic activities", THROMBOSIS AND HAEMOSTASIS, vol. 99, 14 February 2008 (2008-02-14), pages 539 - 545, XP008137123
MELO ET AL.: "An algal sulfated galactan has an unusual dual effect on venous thrombosis due to activation of factor XII and inhibition of the coagulation proteases", THROMBOSIS AND HAEMOSTASIS, vol. 99, 14 February 2008 (2008-02-14), pages 531 - 538, XP008137124
FARIAS ET AL.: "Structure and Anticoagulant Activity of Sulfated Galactans", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 38, 2000, pages 29299 - 29307, XP008137108
MELO ET AL.: "An algal sulfated galactan has an unusual dual effect on venous thrombosis due to activation of factor XII and inhibition of the coagulation proteases", THROMBOSIS AND HAEMOSTASIS, vol. 99, 14 February 2008 (2008-02-14), pages 531 - 538, XP008137124
FARIAS ET AL.: "Structure and Anticoagulant Activity of Sulfated Galactans", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 38, 2000, pages 29299 - 29307, XP008137108
Attorney, Agent or Firm:
GARCIA, Mario Augusto Soerensen et al. (Av. Rio Branco 110 - 11° Andar, -001 Centro - Rio de Janeiro - RJ, BR)
Download PDF: