Title:
SULFATED HYALURONIC ACID-BASED HYDROGEL AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2020/055199
Kind Code:
A1
Abstract:
The present invention relates to a sulfated hyaluronic acid-based hydrogel wherein at least one selected from the group consisting of sulfated hyaluronic acid, a derivative thereof, and a salt thereof is included in an interpenetrating network structure within a hydrogel formed by crosslinking crosslinkable hyaluronic acid monomers with a crosslinking agent, the crosslinkable hyaluronic acid monomers comprising at least one selected from the group consisting of hyaluronic acid, a derivative thereof, and a salt thereof.
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Inventors:
YANG JEONG A (KR)
SO JIN EON (KR)
SEO HAE WON (KR)
JUNG HYUN TAE (KR)
SO JIN EON (KR)
SEO HAE WON (KR)
JUNG HYUN TAE (KR)
Application Number:
PCT/KR2019/011888
Publication Date:
March 19, 2020
Filing Date:
September 11, 2019
Export Citation:
Assignee:
LG CHEMICAL LTD (KR)
International Classes:
A61K31/728; A61K9/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00
Domestic Patent References:
| WO1998045335A1 | 1998-10-15 |
Foreign References:
| KR20120114031A | 2012-10-16 |
Other References:
KHUNMANEE, S. ET AL.: "Crosslinking method of hyaluronic-based hydrogel for biomedical applications", JOURNAL OF TISSUE ENGINEERING, vol. 8, 1 January 2017 (2017-01-01), pages 1 - 16, XP002791499
JORDAN. A. R. ET AL.: "Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer", ONCOTARGET, vol. 8, no. 15, 11 April 2017 (2017-04-11), pages 24262 - 24274, XP055691118, ISSN: 1949-2553, DOI: 10.18632/oncotarget.10529
CEN, L. ET AL.: "Assessment of in vitro bioactivity of hyaluronic acid and sulfated hyaluronic acid functionalized electroactive polymer", BIOMACROMOLECULES, vol. 5, no. 6, 1 November 2004 (2004-11-01), pages 2238 - 2246, XP055232796, ISSN: 1525-7797, DOI: 10.1021/bm040048v
JORDAN. A. R. ET AL.: "Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer", ONCOTARGET, vol. 8, no. 15, 11 April 2017 (2017-04-11), pages 24262 - 24274, XP055691118, ISSN: 1949-2553, DOI: 10.18632/oncotarget.10529
CEN, L. ET AL.: "Assessment of in vitro bioactivity of hyaluronic acid and sulfated hyaluronic acid functionalized electroactive polymer", BIOMACROMOLECULES, vol. 5, no. 6, 1 November 2004 (2004-11-01), pages 2238 - 2246, XP055232796, ISSN: 1525-7797, DOI: 10.1021/bm040048v
Attorney, Agent or Firm:
BAE, KIM & LEE IP GROUP (KR)
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