Title:
SULFATED HYALURONIC ACID-BASED HYDROGELS AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2020/055201
Kind Code:
A1
Abstract:
The present invention relates to sulfated hyaluronic acid-based hydrogels formed by crosslinking, with a crosslinking agent, a crosslinkable monomer comprising at least one selected from the group consisting of: sulfated hyaluronic acid in which some of alcoholic hydroxyl groups of hyaluronic acid are sulfated; and derivatives and salts thereof.
Inventors:
YANG JEONG A (KR)
SO JIN EON (KR)
SEO HAE WON (KR)
JUNG HYUN TAE (KR)
SO JIN EON (KR)
SEO HAE WON (KR)
JUNG HYUN TAE (KR)
Application Number:
PCT/KR2019/011890
Publication Date:
March 19, 2020
Filing Date:
September 11, 2019
Export Citation:
Assignee:
LG CHEMICAL LTD (KR)
International Classes:
A61K31/728; A61K9/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00
Foreign References:
| US20120021968A1 | 2012-01-26 | |||
| EP1313772B1 | 2004-08-04 |
Other References:
KHUNMANEE, S.: "Crosslinking method of hyaluronic-based hydrogel for biomedical applications", JOURNAL OF TISSUE ENGINEERING, vol. 8, 1 January 2017 (2017-01-01), pages 1 - 16, XP002791499
JORDAN , A. R. ET AL: "Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer", ONCOTARGET, vol. 8, no. 15, 11 April 2017 (2017-04-11), pages 24262 - 24274, XP055691118, ISSN: 1949-2553, DOI: 10.18632/oncotarget.10529
FENG, Q.ET AL: "Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy", ACTA BIOMATERIALIA, vol. 53, 1 April 2017 (2017-04-01), pages 329 - 342, XP055691121, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.02.015
JORDAN , A. R. ET AL: "Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer", ONCOTARGET, vol. 8, no. 15, 11 April 2017 (2017-04-11), pages 24262 - 24274, XP055691118, ISSN: 1949-2553, DOI: 10.18632/oncotarget.10529
FENG, Q.ET AL: "Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy", ACTA BIOMATERIALIA, vol. 53, 1 April 2017 (2017-04-01), pages 329 - 342, XP055691121, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.02.015
Attorney, Agent or Firm:
BAE, KIM & LEE IP GROUP (KR)
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