Title:
SULFONAMIDE COMPOUND AND PHARMACEUTICAL THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/095822
Kind Code:
A1
Abstract:
A compound having an 11β-HSD1 inhibiting potency. Compounds of the general formula: (wherein all the characters have the same meanings as defined in the description), their salts or hydrates and prodrugs thereof have an 11β-HSD1 inhibiting potency and thus are useful in the prevention and/or treatment of diseases attributed to overproduction of adrenocortical hormone, for example, metabolic diseases (for example, diabetes mellitus (e.g., type II diabetes mellitus, etc.), impaired glucose tolerance, hyperglycemia, insulin resistance, elevated levels of insulin in the plasma, lipid metabolism abnormality, fatty liver, dyslipidemia, hyperlipemia, hypertriglyceridemia, hyper-LDL-cholesterolemia, hypo-HDL-cholesterolemia, obesity, atherosclerosis, syndrome X, metabolic syndrome, Cushing’s syndrome, osteoporosis, etc.), hypertension, receptive defect, memory disorder, depression, anxiety, dementia, Alzheimer disease, glaucoma, immunologic disease, etc.
Inventors:
EGASHIRA HIROMU (JP)
NISHIYAMA EIJI (JP)
NISHIYAMA EIJI (JP)
Application Number:
PCT/JP2006/304623
Publication Date:
September 14, 2006
Filing Date:
March 09, 2006
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
EGASHIRA HIROMU (JP)
NISHIYAMA EIJI (JP)
EGASHIRA HIROMU (JP)
NISHIYAMA EIJI (JP)
International Classes:
C07D211/28; A61K31/44; A61K31/451; A61K31/4535; A61K31/454; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P5/46; A61P9/10
Domestic Patent References:
| WO2005011653A2 | 2005-02-10 | |||
| WO2005013914A2 | 2005-02-17 | |||
| WO2004092136A1 | 2004-10-28 | |||
| WO2005060963A1 | 2005-07-07 | |||
| WO2005108370A1 | 2005-11-17 |
Foreign References:
| JPS5813520A | 1983-01-26 | |||
| JP2000344746A | 2000-12-12 | |||
| US2712012A | 1955-06-28 |
Other References:
HAMDOUCHI C. ET AL.: "Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses: Design, Synthesis, and Biological Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 20, 2003, pages 4333 - 4341, XP003002230
KUKOLJA S. ET AL.: "Nucleophilic substitution, demethylation, and methylation in heterocyclic series", CHEMICAL ABSTRACTS, vol. 59, no. ABSTRACT NO. 10034C, 1963, XP003003363
KUKOLJA S. ET AL.: "Nucleophilic substitution, demethylation, and methylation in heterocyclic series", CHEMICAL ABSTRACTS, vol. 59, no. ABSTRACT NO. 10034C, 1963, XP003003363
Attorney, Agent or Firm:
Iwatani, Ryo (1-31 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, JP)
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