Title:
SULFONAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/042238
Kind Code:
A1
Abstract:
The invention provides a novel sulfonamide compound useful as a drug having a TRPM8-blocking effect. Specifically, the invention provides a sulfonamide compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, ring A is formula (i), (ii), or (ix), R4 is an optionally substituted alkyl, X1 and X2 are each independently tetrazolyl, tetrazolinonyl, optionally substituted triazolyl, triazolinonyl, oxadiazolonyl, optionally substituted alkanoylaminomethyl, or optionally substituted alkylsulfonylaminomethyl, or R4 and X2 bond to each other at the ends and form indazolinonyl or benzoisoxazolonyl with the adjacent benzene; other symbols are as stated in the specification.)
Inventors:
KATO TAKU (JP)
SAKAMOTO TOSHIAKI (JP)
KUBO AKIRA (JP)
SAWAMOTO DAISUKE (JP)
SAKAMOTO TOSHIAKI (JP)
KUBO AKIRA (JP)
SAWAMOTO DAISUKE (JP)
Application Number:
PCT/JP2013/074812
Publication Date:
March 20, 2014
Filing Date:
September 13, 2013
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
C07D217/22; A61K31/472; A61K31/4725; A61K31/5377; A61P1/00; A61P11/00; A61P13/00; A61P15/00; A61P17/00; A61P25/00; A61P25/04; A61P25/06; A61P35/00; A61P43/00; C07D401/12; C07D401/14; C07D413/12; C07D413/14
Domestic Patent References:
| WO2009012430A1 | 2009-01-22 | |||
| WO2010125831A1 | 2010-11-04 | |||
| WO2012124825A1 | 2012-09-20 | |||
| WO2012078994A1 | 2012-06-14 | |||
| WO2012042915A1 | 2012-04-05 | |||
| WO2010144680A1 | 2010-12-16 | |||
| WO2009012430A1 | 2009-01-22 | |||
| WO2010144680A1 | 2010-12-16 | |||
| WO2010125831A1 | 2010-11-04 |
Other References:
D. D. MCKEMY: "Identification of a cold receptor reveals a general role for TRP channels in thermosensation", NATURE, vol. 416, no. 6876, 2002, pages 52 - 58, XP002250383, DOI: doi:10.1038/nature719
J. ABE: "Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8", NEUROSCIENCE LETTERS, vol. 397, no. 1-2, 2006, pages 140 - 144, XP025024002, DOI: doi:10.1016/j.neulet.2005.12.005
L. S. PREMKUMAR: "Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation", JOURNAL OF NEUROSCIENCE, vol. 25, no. 49, 2005, pages 11322 - 11329
H. XING: "TRPM8 Mechanism of Cold Allodynia after Chronic Nerve Injury", JOURNAL OF NEUROSCIENCE, vol. 27, no. 50, 2007, pages 13680 - 13690
P. GAUCHAN: "Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice", NEUROSCIENCE LETTERS, vol. 458, no. 2, 2009, pages 93 - 95, XP026104857, DOI: doi:10.1016/j.neulet.2009.04.029
T. W. GREENE ET AL.: "Protecting Groups in Organic Synthesis", 2006, JOHN WILEY & SONS
J. ABE: "Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8", NEUROSCIENCE LETTERS, vol. 397, no. 1-2, 2006, pages 140 - 144, XP025024002, DOI: doi:10.1016/j.neulet.2005.12.005
L. S. PREMKUMAR: "Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation", JOURNAL OF NEUROSCIENCE, vol. 25, no. 49, 2005, pages 11322 - 11329
H. XING: "TRPM8 Mechanism of Cold Allodynia after Chronic Nerve Injury", JOURNAL OF NEUROSCIENCE, vol. 27, no. 50, 2007, pages 13680 - 13690
P. GAUCHAN: "Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice", NEUROSCIENCE LETTERS, vol. 458, no. 2, 2009, pages 93 - 95, XP026104857, DOI: doi:10.1016/j.neulet.2009.04.029
T. W. GREENE ET AL.: "Protecting Groups in Organic Synthesis", 2006, JOHN WILEY & SONS
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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