SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY

WIPO Patent Application WO/2007/037187

A1

A sulfonamide derivative having DP receptor antagonistic activity; and a medicinal composition and a therapeutic agent for allergic diseases which each contains the compound as an active ingredient. The derivative is a compound represented by the general formula (II): (II) (wherein ring A is an aromatic carbocycle, etc.; ring B is a nitrogenous nonaromatic heterocycle, etc.; ring C is an aromatic carbocycle, etc.; R1 is carboxy, etc.; R2's each independently is halogeno, etc.; R3 is optionally substituted alkyloxy, etc.; R4's each independently is halogeno, etc.; R5's each independently is optionally substituted alkyl, etc.; M is sulfonyl, etc.; Y is a single bond, etc.; L1 is a single bond, etc.; L2 is a single bond, etc.; k is 0, 1, 2, 3, or 4; n is 0, 1, or 2; and q is 0, 1, 2, or 3, provided that, for example, a) when ring B is a 6-membered nitrogenous heterocycle containing one or two nitrogen atoms and ring C is a benzene ring, then k is not 0), a pharmaceutically acceptable salt of the compound, or a hydrate of either.

KUGIMIYA AKIRA (JP)
FUJIOKA MASAHIKO (JP)
TACHIBANA YUKI (JP)
MURASHI TAKAMI (JP)
ONODERA NAOHIRO (JP)

PCT/JP2006/318917

April 05, 2007

September 25, 2006

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SHIONOGI & CO (JP)
KUGIMIYA AKIRA (JP)
FUJIOKA MASAHIKO (JP)
TACHIBANA YUKI (JP)
MURASHI TAKAMI (JP)
ONODERA NAOHIRO (JP)

C07D207/48; A61K31/40; A61K31/445; A61K31/451; A61K31/4545; A61K31/495; A61K31/496; A61P11/06; A61P37/08; A61P43/00; C07D207/14; C07D211/58; C07D211/70; C07D211/96; C07D213/38; C07D213/71; C07D213/74; C07D231/12; C07D235/08; C07D235/32; C07D261/18; C07D263/32; C07D265/36; C07D271/10; C07D277/28; C07D285/12; C07D295/22; C07D307/52; C07D307/56; C07D401/12; C07D413/12

WO2003097598A1	2003-11-27
WO1993012086A1	1993-06-24
WO2004073606A2	2004-09-02
WO2003078409A1	2003-09-25
WO2004089884A1	2004-10-21
WO2004089885A1	2004-10-21
WO2006056752A1	2006-06-01
WO2006059801A1	2006-06-08

JP2005525380A	2005-08-25
JPH072784A	1995-01-06
JP2005502632A	2005-01-27
JPS5872575A	1983-04-30
JPH03275678A	1991-12-06
JPH03275679A	1991-12-06

SATO M. ET AL.: "Synthesis and Evaluation of Novel Thiazolidine Derivatives as Thromboxane A2 Receptor Antagonists", CHEMICAL PHARMACEUTICAL BULLETIN, vol. 42, no. 3, 1994, pages 521 - 529, XP008054432
HIRAI H.: "Alergy to PGD2", FOLIA PHARMACOLOGICA JAPONICA, vol. 123, no. 1, 2004, pages 15 - 22, XP003011347
DATABASE CHEMCATS [online] XP003011348, accession no. STN Database accession no. (2006:4680082)
DATABASE CHEMCATS [online] XP003011349, accession no. STN Database accession no. (2006:4680073)
DATABASE CHEMCATS [online] XP003011350, accession no. STN Database accession no. (2006:1161483)
DATABASE CHEMCATS [online] XP003011351, accession no. STN Database accession no. (2005:3505772)
See also references of EP 1939175A4

TAKAYAMA, Hirotsugu et al. (Ltd. Intellectual Property Department, 12-4, Sagisu 5-chome, Fukushima-ku, Osaka-sh, Osaka 02, JP)

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