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Title:
SULFONAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION SALT
Document Type and Number:
WIPO Patent Application WO/2019/117148
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel low molecular-weight compound having orexin receptor agonist activity that is expected to be useful for the prevention or treatment of narcolepsy, etc. The present invention provides: a compound represented by formula (I) that has orexin receptor agonist activity (the symbols in the formula are the same as defined in the description) or a pharmaceutically acceptable acid-addition salt thereof; and an orexin receptor agonist comprising the compound or pharmaceutically acceptable acid-addition salt thereof.

Inventors:
NAGASE, Hiroshi (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
SAITOH, Tsuyoshi (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
YANAGISAWA, Masashi (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
IRUKAYAMA, Yoko (1-1-1 Tennodai, Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
Application Number:
JP2018/045523
Publication Date:
June 20, 2019
Filing Date:
December 11, 2018
Export Citation:
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Assignee:
UNIVERSITY OF TSUKUBA (1-1-1, Tennodai Tsukuba-sh, Ibaraki 77, 〒3058577, JP)
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (210 W. 7th Street, Austin Texas, 78701, US)
International Classes:
C07D239/10; A61K31/513; A61P3/04; A61P3/10; A61P9/00; A61P21/00; A61P25/00; A61P25/08; A61P25/18; A61P25/24; A61P25/26; A61P43/00; C07D403/12
Domestic Patent References:
WO2016199906A12016-12-15
WO2015088000A12015-06-18
WO2016133160A12016-08-25
WO2015152367A12015-10-08
Foreign References:
JP2002536447A2002-10-29
JP2015521999A2015-08-03
Other References:
MORENO, ANTONIO ET AL.: "Synthesis and evaluation of new [(arylsulfonamido)methyl]cyclohexyl derivatives as human neuropeptide Y Y5 receptor antagonists for the treatment of obesity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, no. 1, 2004, pages 49 - 58, XP055617715, DOI: 10.1016/j.ejmech.2003.10.001
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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