SULFONAMIDE DERIVATIVES

Title:

SULFONAMIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2001/023363

Kind Code:

A1

Abstract:

Compounds of general formula (I) exhibiting inhibitory activities against matrix metalloproteinase 13 and aggrecanase, wherein R?1¿ is OH or NHOH; R?2¿ is a group of general formula (II) or (III); A is alkylene which may be interrupted by an ether linkage or the like; R?3¿ is hydrogen, alkyl, or the like; L is optionally substituted (hetero)arylene; M is oxygen or sulfur; and R?4¿ is optionally substituted alkyl, (hetero)aryl, or the like.

Inventors:

KIMURA TOMIO (JP)
TAMAKI KAZUHIKO (JP)
MIYAZAKI SHOUJIRO (JP)
KURAKATA SHINICHI (JP)
FUJIWARA KOSAKU (JP)

Application Number:

PCT/JP2000/006798

Publication Date:

April 05, 2001

Filing Date:

September 29, 2000

Export Citation:

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Assignee:

SANKYO CO (JP)
KIMURA TOMIO (JP)
TAMAKI KAZUHIKO (JP)
MIYAZAKI SHOUJIRO (JP)
KURAKATA SHINICHI (JP)
FUJIWARA KOSAKU (JP)

International Classes:

A61P19/02; A61P35/00; C07D239/54; C07D277/34; (IPC1-7): C07D239/54; A61K31/4166; A61K31/421; A61K31/426; A61K31/513; A61K31/517; A61K31/519; A61P19/02; A61P35/00; C07D233/40; C07D239/553; C07D239/70; C07D263/44; C07D277/34; C07D471/04; C07D487/04; C07D495/04

Domestic Patent References:

WO1999051572A1	1999-10-14
WO1999042443A1	1999-08-26
WO1999006340A2	1999-02-11
WO1997027174A1	1997-07-31