Title:
SULFONYLUREA COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020412
Kind Code:
A1
Abstract:
The present invention relates to a sulfonylurea compound represented by formula I, a preparation method therefore, and an application thereof. The compound of the present invention has soluble epoxide hydrolase (sEH) inhibitory activity and can increase the level of epoxyeicosatrienoic acids (EETs) so as to alleviate inflammatory responses, and thus can be used for preventing and treating heart failure. The preparation method of the present invention has the technical advantages of simple steps, high yield, and easily available raw materials.
Inventors:
WANG DAOWEN (CN)
JIANG XIANGRUI (CN)
CHEN CHEN (CN)
JIANG HUALIANG (CN)
SHEN JINGSHAN (CN)
JIANG XIANGRUI (CN)
CHEN CHEN (CN)
JIANG HUALIANG (CN)
SHEN JINGSHAN (CN)
Application Number:
PCT/CN2022/112383
Publication Date:
February 23, 2023
Filing Date:
August 15, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
TONGJI HOSPITAL AFFILIATED TO TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV OF SCIENCE & TECHNOLOGY (CN)
TONGJI HOSPITAL AFFILIATED TO TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV OF SCIENCE & TECHNOLOGY (CN)
International Classes:
C07C311/57; A61K31/64; A61P9/04; A61P29/00; C07C311/54; C07C311/56; C07C311/58; C07C311/59; C07C311/60; C07D207/267; C07D207/38; C07D209/52; C07D213/74; C07D217/24; C07D241/24
Domestic Patent References:
| WO2005040101A1 | 2005-05-06 |
Foreign References:
| CN106176743A | 2016-12-07 | |||
| CN1134415A | 1996-10-30 | |||
| CN1134414A | 1996-10-30 | |||
| CN1134421A | 1996-10-30 | |||
| CN110161242A | 2019-08-23 | |||
| CN111423396A | 2020-07-17 | |||
| CN105980391A | 2016-09-28 |
Other References:
BRASELTON W E, ET AL.: "GAS CHROMATOGRAPHIC AND MASS SPECTRAL PROPERTIES OF SULFONYLUREA N-METHYL-N'-PERFLUOROACYL DERIVATIVES", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 09, 1 August 1976 (1976-08-01), US , pages 1386 - 1394, XP001161287, ISSN: 0003-2700, DOI: 10.1021/ac50003a030
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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