Title:
SULFONYLUREA DERIVATIVES AND DRUGS CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/1999/048864
Kind Code:
A1
Abstract:
Sulfonylurea derivatives represented by general formula (1) or salts thereof and optically active intermediates thereof; a process for producing these compounds; and drugs containing these sulfonylurea derivatives or salts thereof as the active ingredient, wherein R?1¿ represents hydrogen, optionally substituted acyl or alkoxycarbonyl; R?2¿ and R?3¿ represent each alkyl; and * represents an asymmetric carbon atom, provided that the case where the absolute configuration at * is S, R?1¿ is hydrogen, R?2¿ is methyl and R?3¿ is cyclohexyl is excluded. These compounds have an immediate- and short-acting hypoglycemic effect.
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Inventors:
AKITA HIROYUKI (JP)
IMAMURA YORISHIGE (JP)
SANUI KAZUKO (JP)
KURASHIMA KATSUMI (JP)
KURASHIMA KAZUYO (JP)
SERI KENJI (JP)
IMAMURA YORISHIGE (JP)
SANUI KAZUKO (JP)
KURASHIMA KATSUMI (JP)
KURASHIMA KAZUYO (JP)
SERI KENJI (JP)
Application Number:
PCT/JP1999/001466
Publication Date:
September 30, 1999
Filing Date:
March 24, 1999
Export Citation:
Assignee:
GODO SHUSEI KK (JP)
AKITA HIROYUKI (JP)
IMAMURA YORISHIGE (JP)
SANUI KAZUKO (JP)
KURASHIMA KATSUMI (JP)
KURASHIMA KAZUYO (JP)
SERI KENJI (JP)
AKITA HIROYUKI (JP)
IMAMURA YORISHIGE (JP)
SANUI KAZUKO (JP)
KURASHIMA KATSUMI (JP)
KURASHIMA KAZUYO (JP)
SERI KENJI (JP)
International Classes:
C07C311/58; (IPC1-7): C07C311/58; A61K31/64; C07C303/40; C07C311/29; C12P41/00
Domestic Patent References:
WO1996036617A1 | 1996-11-21 | |||
WO1997006136A1 | 1997-02-20 |
Other References:
INUI S., ASADA S.: "OXIDIZED METABOLITES OF P-(PLUS OR MINUS)-ALPHA-HYDROXYETHYLBENZENESULFONAMIDE AND P-(PLUS OR MINUS)-ALPHA-HYDROXYETHYLBENZENESULFONYLUREA DERIVATIVES APPEARED IN RAT PLASMA.", YAKUGAKU ZASSHI = JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 107., no. 11., 1 January 1987 (1987-01-01), JP, pages 904 - 909., XP002920087, ISSN: 0031-6903
IMAMURA Y., ET AL.: "STEREOSELECTIVE REDUCTION OF ACETOHEXAMIDE IN CYTOSOL OF RABBIT LIVER.", JOURNAL OF PHARMACOBIO-DYNAMICS, TOKYO, JP, vol. 12., no. 12., 1 January 1989 (1989-01-01), JP, pages 731 - 735., XP002920088, ISSN: 0386-846X
IMAMURA Y., KOJIMA Y., OTAGIRI M.: "METABOLIC REDUCTION OF ACETOHEXAMIDE IN RAT LIVER AND KIDNEY.", YAKUGAKU ZASSHI = JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 108., no. 08., 1 January 1988 (1988-01-01), JP, pages 758 - 762., XP002920089, ISSN: 0031-6903
AKITA H., ET AL.: "DETERMINATION OF ABSOLUTE CONFIGURATION OF A METABOLITE (-)-HYDROXYHEXAMIDE FROM ACETOHEXAMIDE, SYNTHESES OF (-)- AND (+)-HYDROXYHEXAMIDES AND (-)- AND (+)-ACETOXYHEXAMIDES.", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 09., no. 24., 1 January 1998 (1998-01-01), OXFORD, GB, pages 4331 - 4340., XP002920090, ISSN: 0957-4166, DOI: 10.1016/S0957-4166(98)00436-4
IMAMURA Y., ET AL.: "STEREOSELECTIVE REDUCTION OF ACETOHEXAMIDE IN CYTOSOL OF RABBIT LIVER.", JOURNAL OF PHARMACOBIO-DYNAMICS, TOKYO, JP, vol. 12., no. 12., 1 January 1989 (1989-01-01), JP, pages 731 - 735., XP002920088, ISSN: 0386-846X
IMAMURA Y., KOJIMA Y., OTAGIRI M.: "METABOLIC REDUCTION OF ACETOHEXAMIDE IN RAT LIVER AND KIDNEY.", YAKUGAKU ZASSHI = JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 108., no. 08., 1 January 1988 (1988-01-01), JP, pages 758 - 762., XP002920089, ISSN: 0031-6903
AKITA H., ET AL.: "DETERMINATION OF ABSOLUTE CONFIGURATION OF A METABOLITE (-)-HYDROXYHEXAMIDE FROM ACETOHEXAMIDE, SYNTHESES OF (-)- AND (+)-HYDROXYHEXAMIDES AND (-)- AND (+)-ACETOXYHEXAMIDES.", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 09., no. 24., 1 January 1998 (1998-01-01), OXFORD, GB, pages 4331 - 4340., XP002920090, ISSN: 0957-4166, DOI: 10.1016/S0957-4166(98)00436-4
Attorney, Agent or Firm:
Aruga, Mitsuyuki (3-6 Nihonbashiningyocho 1-chom, Chuo-ku Tokyo, JP)
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