Title:
SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2, 3-DIOXYGENASE
Document Type and Number:
WIPO Patent Application WO/2018/095432
Kind Code:
A1
Abstract:
Provided are certain IDO inhibitors, pharmaceutical compositions thereof, and methods of use thereof.
Inventors:
CHEN ZHIFANG (CN)
TAN RUI (CN)
LIU QIHONG (CN)
YANG LIJUN (CN)
LI ZHIFU (CN)
TAN HAOHAN (CN)
LIU HONGBIN (CN)
ZHAO XINGDONG (CN)
LIN MIN (CN)
SUN JING (CN)
WANG WEIBO (US)
TAN RUI (CN)
LIU QIHONG (CN)
YANG LIJUN (CN)
LI ZHIFU (CN)
TAN HAOHAN (CN)
LIU HONGBIN (CN)
ZHAO XINGDONG (CN)
LIN MIN (CN)
SUN JING (CN)
WANG WEIBO (US)
Application Number:
PCT/CN2017/113254
Publication Date:
May 31, 2018
Filing Date:
November 28, 2017
Export Citation:
Assignee:
SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN)
CHONGQING FOCHON PHARMACEUTICAL CO LTD (CN)
CHONGQING FOCHON PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D271/08; A61K31/4245; A61P31/12; A61P35/00; A61P37/00
Domestic Patent References:
| WO2006122150A1 | 2006-11-16 | |||
| WO2016041489A1 | 2016-03-24 | |||
| WO2010005958A2 | 2010-01-14 | |||
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PURE APPL. CHEM., vol. 45, 1976, pages 13 - 10
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KATO ET AL., J. LABELLED COMP. RADIOPHARMACEUT., vol. 36, no. 10, 1995, pages 927 - 932
KUSHNER ET AL., CAN. J. PHYSIOL. PHARMACOL, vol. 77, 1999, pages 79 - 88
CZAJKA D MFINKEL A J, ANN. N.Y. ACAD. SCI., vol. 84, 1960, pages 770
THOMSON J F, ANN. NEW YORK ACAD. SCI, vol. 84, 1960, pages 736
CZAKJA D M ET AL., AM. J. PHYSIOL., vol. 201, 1961, pages 357
BLAGOJEVIC N ET AL.: "Advanced Medical Publishing, Madison Wis", 1994, article "Dosimetry & Treatment Planning for Neutron Capture Therapy", pages: 125 - 134
DIABETES METAB, vol. 23, 1997, pages 251
T. W. GREENE: "Protecting Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
TETRAHEDRON, vol. 70, 2014, pages 6613
ANGEW. CHEM. INT. ED., vol. 55, 2016, pages 7203
ADVANCED SYNTHESIS AND CATALYSIS, vol. 358, 2016, pages 380
See also references of EP 3544965A4
NATURE MEDICINE, vol. 11, 2005, pages 312
NATURE MED., vol. 9, 2003, pages 1269
NATURE MED., vol. 11, 2005, pages 312
INT. J. CANCER, vol. 101, 2002, pages 151
BR J CANCER., vol. 86, 2002, pages 1691
DERMATOLOGY, vol. 214, 2007, pages 8
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", 2000, PLENUM PRESS
T.W. GREENEP. G. M. WUTS: "Protective Groups in Organic Chemistry", 1991, JOHN WILEY AND SONS
C. D. JONESM. KASELJR. N. SALVATOREW. J. LE NOBLE, J. ORG. CHEM., vol. 63, 1998, pages 2758 - 2760
PURE APPL. CHEM., vol. 45, 1976, pages 13 - 10
LIZONDO, J ET AL., DRUGS FUT, vol. 21, no. 11, 1996, pages 1116
BRICKNER, S J ET AL., J MED CHEM, vol. 39, no. 3, 1996, pages 673
MALLESHAM, B ET AL., ORG LETT, vol. 5, no. 7, 2003, pages 963
BLAKE ET AL., J. PHARM. SCI., vol. 64, no. 3, 1975, pages 367 - 391
FOSTER ET AL.: "Advances in Drug Research", vol. 14, 1985, ACADEMIC PRESS, pages: 2 - 36
KATO ET AL., J. LABELLED COMP. RADIOPHARMACEUT., vol. 36, no. 10, 1995, pages 927 - 932
KUSHNER ET AL., CAN. J. PHYSIOL. PHARMACOL, vol. 77, 1999, pages 79 - 88
CZAJKA D MFINKEL A J, ANN. N.Y. ACAD. SCI., vol. 84, 1960, pages 770
THOMSON J F, ANN. NEW YORK ACAD. SCI, vol. 84, 1960, pages 736
CZAKJA D M ET AL., AM. J. PHYSIOL., vol. 201, 1961, pages 357
BLAGOJEVIC N ET AL.: "Advanced Medical Publishing, Madison Wis", 1994, article "Dosimetry & Treatment Planning for Neutron Capture Therapy", pages: 125 - 134
DIABETES METAB, vol. 23, 1997, pages 251
T. W. GREENE: "Protecting Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
TETRAHEDRON, vol. 70, 2014, pages 6613
ANGEW. CHEM. INT. ED., vol. 55, 2016, pages 7203
ADVANCED SYNTHESIS AND CATALYSIS, vol. 358, 2016, pages 380
See also references of EP 3544965A4
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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