Title:
SULFUR-CONTAINING BICYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/056771
Kind Code:
A1
Abstract:
[Problem] To provide a compound useful as a pharmaceutical composition for prevention and/or treatment of diseases such as schizophrenia. [Solution] The inventors developed the present invention upon investigating a pharmaceutical composition having effects as a GABAB positive allosteric modulator (effects as a PAM), for preventing/treating diseases such as schizophrenia, and confirming that a sulfur-containing bicyclic compound has effects as a GABAB PAM. This sulfur-containing bicyclic compound has effects as a GABAB PAM and can be used as a preventive and/or therapeutic agent for diseases such as schizophrenia. (In the formula, X represents CH, R1 represents a lower alkyl, R2 represents a lower alkyl , R3 represents –H, R4 represents –H, ring A is a cyclohexane ring, RY represents a group represented by formula (III), Y represents NH, etc., and RL represents a lower alkyl.)
Inventors:
SHIRAISHI NOBUYUKI (JP)
HOSHII HIROAKI (JP)
HAMAGUCHI WATARU (JP)
HONJO ERIKO (JP)
TAKUWA TOMOFUMI (JP)
KONDO YUJI (JP)
GOTO TAKAYUKI (JP)
HOSHII HIROAKI (JP)
HAMAGUCHI WATARU (JP)
HONJO ERIKO (JP)
TAKUWA TOMOFUMI (JP)
KONDO YUJI (JP)
GOTO TAKAYUKI (JP)
Application Number:
PCT/JP2014/077653
Publication Date:
April 23, 2015
Filing Date:
October 17, 2014
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
C07D495/04; A61K31/519; A61K31/5377; A61K31/541; A61K31/554; A61P25/00; A61P25/18; A61P25/22; A61P43/00; C07D519/00
Domestic Patent References:
| WO2002062803A1 | 2002-08-15 | |||
| WO2006030031A1 | 2006-03-23 | |||
| WO2002062803A1 | 2002-08-15 | |||
| WO2004089312A2 | 2004-10-21 |
Foreign References:
| JP2013503906A | 2013-02-04 | |||
| JP2007509960A | 2007-04-19 | |||
| JP2008524134A | 2008-07-10 | |||
| JP2008513413A | 2008-05-01 | |||
| JP2006522141A | 2006-09-28 |
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CELL, vol. 146, no. 2, July 2011 (2011-07-01), pages 247 - 261
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 310, 2004, pages 952 - 963
ADVANCES IN PHARMACOLOGY, vol. 58, 2010, pages 373 - 396
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SYNAPSE, vol. 50, no. 1, October 2003 (2003-10-01), pages 1 - 6
EUROPEAN JOURNAL OF PAIN, vol. 8, no. 4, August 2004 (2004-08-01), pages 377 - 383
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 310, no. 3, September 2004 (2004-09-01), pages 952 - 963
PSYCHOPHARMACOLOGY (BERL, vol. 215, no. 1, May 2011 (2011-05-01), pages 117 - 128
"International Classification of Diseases of WHO"
"Statistical Manual of Mental Diagnosis", AMERICAN PSYCHIATRIC ASSOCIATION
PROGRESS IN MEDICINE, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", vol. 1, 1991, ACADEMIC PRESS INC.
"Jikken Kagaku Koza", vol. 14, 2005, MARUZEN
A. R. KATRITZKY; R. J. K. TAYLOR: "Comprehensive Organic Functional Group Transformations II", vol. 2, 2005, ELSEVIER PERGAMON
"Courses in Experimental Chemistry", vol. 14, 2005, MARUZEN
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", 1991, ACADEMIC PRESS INC.
"Jikken Kagaku Koza", vol. 16, 2005, MARUZEN
M. HUDLICKY: "Reductions in Organic Chemistry", 1996, ACS
"Jikken Kagaku Koza", vol. 19, 2005, MARUZEN
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, VCH PUBLISHERS, INC.
T. J. DONOHOE: "Oxidation and Reduction in Organic Synthesis", 2000, OXFORD SCIENCE PUBLICATIONS
GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC
NEGISHI, E., ACC. CHEM. RES., vol. 15, 1982, pages 340 - 348
"Metal-Catalyzed Cross-Coupling Reactions", 2004, VCH PUBLISHERS INC.
"Jikken Kagaku Koza", vol. 13, 2005, MARUZEN
ORGANIC LETTERS, 2004, pages 3225
SYNLETT, 2008, pages 543
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 307, no. 1, 2003, pages 322 - 330
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 187, no. 1, 1990, pages 27 - 38
NATURE, vol. 386, 1997, pages 239 - 246
NATURE, vol. 396, 1998, pages 683 - 687
PAIN, vol. 146, 2009, pages 26 - 33
See also references of EP 3059239A4
NEUROPHARMACOLOGY, vol. 60, no. 1, January 2011 (2011-01-01), pages 82 - 92
TRENDS IN NEUROSCIENCES, vol. 35, no. 1, 2012, pages 57 - 67
MOLECULAR PSYCHIATRY, vol. 8, no. 8, 2003, pages 721 - 737,715
FRONTIERS IN PSYCHIATRY, vol. 3, 2012, pages 51
NEUROSCIENCE & BIOBEHAVIORAL REVIEWS, vol. 36, no. 9, October 2012 (2012-10-01), pages 2044 - 2055
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 602, no. 1, 2009, pages 101 - 104
NEUROPSYCHOPHARMACOLOGY, vol. 33, no. 13, December 2008 (2008-12-01), pages 3164 - 3175
TRANSLATIONAL PSYCHIATRY, vol. 2, 17 July 2012 (2012-07-17), pages E 142
SCIENCE TRANSLATIONAL MEDICINE, vol. 4, no. 152, 19 September 2012 (2012-09-19), pages 152RA127
JOURNAL OF AUTISM AND DEVELOPMENT DISORDERS, vol. 44, no. 4, April 2014 (2014-04-01), pages 958 - 964
NATURE, vol. 492, December 2012 (2012-12-01), pages 382 - 386
CELL, vol. 146, no. 2, July 2011 (2011-07-01), pages 247 - 261
NEUROLOGY, vol. 63, no. 8, 26 October 2004 (2004-10-26), pages 1357 - 1363
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 310, 2004, pages 952 - 963
ADVANCES IN PHARMACOLOGY, vol. 58, 2010, pages 373 - 396
DRUG AND ALCOHOL DEPENDENCE, vol. 65, no. 3, 2002, pages 209 - 220
SYNAPSE, vol. 50, no. 1, October 2003 (2003-10-01), pages 1 - 6
EUROPEAN JOURNAL OF PAIN, vol. 8, no. 4, August 2004 (2004-08-01), pages 377 - 383
NEUROGASTROENTEROLOGY AND MOTILITY, vol. 24, no. 6, June 2012 (2012-06-01), pages 553 - 559,E253
PAIN, vol. 152, 2011, pages 1007 - 1017
EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 19, no. 10, May 2004 (2004-05-01), pages 2641 - 2649
NATURE REVIEWS DRUG DISCOVERY, vol. 11, 2012, pages 589
NEUROSCIENCE, vol. 100, no. 1, 2000, pages 155 - 170
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 41, 13 October 2000 (2000-10-13), pages 32174 - 32181
MOLECULAR PHARMACOLOGY, vol. 60, no. 5, 2001, pages 963 - 971
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 310, no. 3, September 2004 (2004-09-01), pages 952 - 963
PSYCHOPHARMACOLOGY (BERL, vol. 215, no. 1, May 2011 (2011-05-01), pages 117 - 128
"International Classification of Diseases of WHO"
"Statistical Manual of Mental Diagnosis", AMERICAN PSYCHIATRIC ASSOCIATION
PROGRESS IN MEDICINE, 1985, pages 2157 - 2161
"Drug Design", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "Pharmaceutical Research and Development", pages: 163 - 198
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 2006
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", vol. 1, 1991, ACADEMIC PRESS INC.
"Jikken Kagaku Koza", vol. 14, 2005, MARUZEN
A. R. KATRITZKY; R. J. K. TAYLOR: "Comprehensive Organic Functional Group Transformations II", vol. 2, 2005, ELSEVIER PERGAMON
"Courses in Experimental Chemistry", vol. 14, 2005, MARUZEN
S. R. SANDLER; W. KARO: "Organic Functional Group Preparations", 1991, ACADEMIC PRESS INC.
"Jikken Kagaku Koza", vol. 16, 2005, MARUZEN
M. HUDLICKY: "Reductions in Organic Chemistry", 1996, ACS
"Jikken Kagaku Koza", vol. 19, 2005, MARUZEN
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, VCH PUBLISHERS, INC.
T. J. DONOHOE: "Oxidation and Reduction in Organic Synthesis", 2000, OXFORD SCIENCE PUBLICATIONS
GREENE; WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC
NEGISHI, E., ACC. CHEM. RES., vol. 15, 1982, pages 340 - 348
"Metal-Catalyzed Cross-Coupling Reactions", 2004, VCH PUBLISHERS INC.
"Jikken Kagaku Koza", vol. 13, 2005, MARUZEN
ORGANIC LETTERS, 2004, pages 3225
SYNLETT, 2008, pages 543
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 307, no. 1, 2003, pages 322 - 330
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 187, no. 1, 1990, pages 27 - 38
NATURE, vol. 386, 1997, pages 239 - 246
NATURE, vol. 396, 1998, pages 683 - 687
PAIN, vol. 146, 2009, pages 26 - 33
See also references of EP 3059239A4
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (JP)
Morita 拓 (JP)
Morita 拓 (JP)
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