Title:
SULFUR-CONTAINING PROANTHOCYANIDIN OLIGOMER COMPOSITION AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/103988
Kind Code:
A1
Abstract:
A process for producing a sulfur-containing proanthocyanidin oligomer having its molecular weight lowered to such an extent that absorption of in-plant proanthocyanidins through in vivo intestinal tracts can be facilitated. There are provided a health food composition and medicinal drug composition useful for the treatment and prevention of various life-style related diseases and brain damage caused by generation of active oxygen species, etc. and also useful for prevention of senile decay, which health food composition and medicinal drug composition contain the obtained sulfur-containing proanthocyanidin oligomer as an active ingredient.
Inventors:
NONAKA GEN-ICHIRO (JP)
SUN BUXIANG (JP)
YUAN LAN (JP)
NAKAGAWA TAKASHI (JP)
FUJII HAJIME (JP)
SURH YOUNG-JOON (KR)
SUN BUXIANG (JP)
YUAN LAN (JP)
NAKAGAWA TAKASHI (JP)
FUJII HAJIME (JP)
SURH YOUNG-JOON (KR)
Application Number:
PCT/JP2004/007448
Publication Date:
December 02, 2004
Filing Date:
May 25, 2004
Export Citation:
Assignee:
AMINO UP CHEMICAL CO LTD (JP)
USAIEN PHARMACEUTICAL CO LTD (JP)
NONAKA GEN-ICHIRO (JP)
SUN BUXIANG (JP)
YUAN LAN (JP)
NAKAGAWA TAKASHI (JP)
FUJII HAJIME (JP)
SURH YOUNG-JOON (KR)
USAIEN PHARMACEUTICAL CO LTD (JP)
NONAKA GEN-ICHIRO (JP)
SUN BUXIANG (JP)
YUAN LAN (JP)
NAKAGAWA TAKASHI (JP)
FUJII HAJIME (JP)
SURH YOUNG-JOON (KR)
International Classes:
A23L1/30; A61P3/10; A61P3/12; A61P25/28; A61P39/06; C07D311/62; (IPC1-7): C07D311/62; A61K31/352; A61K35/78; A61P3/10; A61P3/12; A61P25/28; A61P39/06; A23L1/30
Domestic Patent References:
| WO2003024951A1 | 2003-03-27 |
Other References:
HONG C.-Y. ET AL.: "The inhibitory effect of tannins on lipid peroxidation of rat heart mitochondria", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 47, no. 2, 1995, pages 138 - 142, XP001087938
KOLODZIEJ H.: "Thiolysis of birch bark procyanidins: structural dependence in formation of 2,3-cis-3,4-cis-flavan-4 benzylthioethers from procyanidins", PHYTOCHEMISTRY, vol. 29, no. 5, 1990, pages 1671 - 1674, XP002980976
HEMINGWAY R.W. ET AL.: "Heterogeneity of interflavanoid bond location in loblolly pine bark procyanidins", PHYTOCHEMISTRY, vol. 22, no. 1, 1983, pages 275 - 281, XP002980977
FOO L.Y. ET AL.: "Procyanidin dimers and trimers from douglas fir inner bark", PHYTOCHEMISTRY, vol. 28, no. 6, 1989, pages 1743 - 1747, XP002980978
GEISS F. ET AL.: "Proanthocyanidins with (+)-epicatechin units from byrsonima crassifolia bark", PHYTOCHEMISTRY, vol. 39, no. 3, 1995, pages 635 - 643, XP002980979
TANAKA T. ET AL.: "Chemical Evidence for the De-astringency (Insolubilization of Tannins) of Persimmon Fruit", J. CHEM. SOC. PERKIN TRANS., vol. 20, 1994, pages 3013 - 3022, XP002980980
SCHOLZ E. ET AL.: "Proanthocyanidins from Krameria triandra Root", PLANTA MEDICA, vol. 55, no. 4, 1989, pages 379 - 384, XP002957320
TORRES J.L ET AL.: "Cysteinyl-flavan-3-ol Conjugates from Grape Procyanidins. Antioxidant and Antiproliferative Properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 2497 - 2509, XP002980981
KOLODZIEJ H.: "Thiolysis of birch bark procyanidins: structural dependence in formation of 2,3-cis-3,4-cis-flavan-4 benzylthioethers from procyanidins", PHYTOCHEMISTRY, vol. 29, no. 5, 1990, pages 1671 - 1674, XP002980976
HEMINGWAY R.W. ET AL.: "Heterogeneity of interflavanoid bond location in loblolly pine bark procyanidins", PHYTOCHEMISTRY, vol. 22, no. 1, 1983, pages 275 - 281, XP002980977
FOO L.Y. ET AL.: "Procyanidin dimers and trimers from douglas fir inner bark", PHYTOCHEMISTRY, vol. 28, no. 6, 1989, pages 1743 - 1747, XP002980978
GEISS F. ET AL.: "Proanthocyanidins with (+)-epicatechin units from byrsonima crassifolia bark", PHYTOCHEMISTRY, vol. 39, no. 3, 1995, pages 635 - 643, XP002980979
TANAKA T. ET AL.: "Chemical Evidence for the De-astringency (Insolubilization of Tannins) of Persimmon Fruit", J. CHEM. SOC. PERKIN TRANS., vol. 20, 1994, pages 3013 - 3022, XP002980980
SCHOLZ E. ET AL.: "Proanthocyanidins from Krameria triandra Root", PLANTA MEDICA, vol. 55, no. 4, 1989, pages 379 - 384, XP002957320
TORRES J.L ET AL.: "Cysteinyl-flavan-3-ol Conjugates from Grape Procyanidins. Antioxidant and Antiproliferative Properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, 2002, pages 2497 - 2509, XP002980981
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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