Title:
SULODEXIDE FOR USE IN THE TREATMENT OF PATHOLOGIES WHEREIN METALLOPROTEINASES ARE INVOLVED
Document Type and Number:
WIPO Patent Application WO/2011/132161
Kind Code:
A3
Abstract:
The present invention describes sulodexide or at least one of its components for use in the reduction of circulating matrix metalloproteinase (MMPs), in particular MMP-9. Sulodexide and its composition are useful for the treatment of pathologies wherein the MMPs are involved, such as cardiovascular disease, cardiovascular disease caused by diabetes, varicose veins, chronic venous insufficiency (CVI), gastrointestinal ulcers, pulmonary disease, and neoplastic pathologies.
Inventors:
VISCOMI GIUSEPPE CLAUDIO (IT)
MANNELLO FERDINANDO (IT)
BRUNO CRISTIANA (IT)
MANNELLO FERDINANDO (IT)
BRUNO CRISTIANA (IT)
Application Number:
PCT/IB2011/051726
Publication Date:
March 08, 2012
Filing Date:
April 20, 2011
Export Citation:
Assignee:
ALFA WASSERMANN SPA (IT)
VISCOMI GIUSEPPE CLAUDIO (IT)
MANNELLO FERDINANDO (IT)
BRUNO CRISTIANA (IT)
VISCOMI GIUSEPPE CLAUDIO (IT)
MANNELLO FERDINANDO (IT)
BRUNO CRISTIANA (IT)
International Classes:
A61K31/726; A61K31/727; A61K31/737; A61K35/38
Other References:
GADDI ET AL: "Meta-analysis of some results of clinical trials on sulodexide therapy in peripheral occlusive arterial disease", JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, CAMBRIDGE MEDICAL PUBLICATIONS LTD, GB, vol. 24, no. 5, 1 September 1996 (1996-09-01), pages 389 - 406, XP002117945, ISSN: 0300-0605
VERSTRAETE M ET AL: "NOVEL ANTITHROMBOTIC DRUGS IN DEVELOPMENT", DRUGS, ADIS INTERNATIONAL LTD, NZ, vol. 49, no. 6, 1 June 1995 (1995-06-01), pages 856 - 884, XP001063907, ISSN: 0012-6667, DOI: DOI:10.2165/00003495-199549060-00002
CONDORELLI M ET AL: "IPO-V2: A PROSPECTIVE, MULTICENTER, RANDOMIZED, COMPARATIVE CLINICAL INVESTIGATION OF THE EFFECTS OF SULODEXIDE IN PREVENTING CARDIOVASCULAR ACCIDENTS IN THE FIRST YEAR AFTER ACUTE MYOCARDINAL INFARCTION", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 23, no. 1, 1 January 1994 (1994-01-01), pages 27 - 34, XP000882515, ISSN: 0735-1097
COCCHERI SERGIO ET AL: "Randomised, double blind, multicentre, placebo controlled study of sulodexide in the treatment of venous leg ulcers", THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH, DE; US, vol. 87, no. 6, 1 May 2002 (2002-05-01), pages 947 - 952, XP008129237, ISSN: 0340-6245
OFOSU F A: "Pharmacological actions of sulodexide", SEMINARS IN THROMBOSIS AND HEMOSTASIS, STUTTGART, DE, vol. 24, no. 2, 1 January 1998 (1998-01-01), pages 127 - 138, XP008129231, ISSN: 0094-6176
COCCHERI S ET AL: "Sulodexide in the treatment of intermittent claudication. Results of a randomized, double-blind, multicentre, placebo-controlled study", EUROPEAN HEART JOURNAL, vol. 23, no. 13, July 2002 (2002-07-01), pages 1057 - 1065, XP002610488, ISSN: 0195-668X
VERSTRAETE M ET AL: "NOVEL ANTITHROMBOTIC DRUGS IN DEVELOPMENT", DRUGS, ADIS INTERNATIONAL LTD, NZ, vol. 49, no. 6, 1 June 1995 (1995-06-01), pages 856 - 884, XP001063907, ISSN: 0012-6667, DOI: DOI:10.2165/00003495-199549060-00002
CONDORELLI M ET AL: "IPO-V2: A PROSPECTIVE, MULTICENTER, RANDOMIZED, COMPARATIVE CLINICAL INVESTIGATION OF THE EFFECTS OF SULODEXIDE IN PREVENTING CARDIOVASCULAR ACCIDENTS IN THE FIRST YEAR AFTER ACUTE MYOCARDINAL INFARCTION", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 23, no. 1, 1 January 1994 (1994-01-01), pages 27 - 34, XP000882515, ISSN: 0735-1097
COCCHERI SERGIO ET AL: "Randomised, double blind, multicentre, placebo controlled study of sulodexide in the treatment of venous leg ulcers", THROMBOSIS AND HAEMOSTASIS, SCHATTAUER GMBH, DE; US, vol. 87, no. 6, 1 May 2002 (2002-05-01), pages 947 - 952, XP008129237, ISSN: 0340-6245
OFOSU F A: "Pharmacological actions of sulodexide", SEMINARS IN THROMBOSIS AND HEMOSTASIS, STUTTGART, DE, vol. 24, no. 2, 1 January 1998 (1998-01-01), pages 127 - 138, XP008129231, ISSN: 0094-6176
COCCHERI S ET AL: "Sulodexide in the treatment of intermittent claudication. Results of a randomized, double-blind, multicentre, placebo-controlled study", EUROPEAN HEART JOURNAL, vol. 23, no. 13, July 2002 (2002-07-01), pages 1057 - 1065, XP002610488, ISSN: 0195-668X
Download PDF:
Previous Patent: METHOD FOR GENERATING AND READING AN HYBRID CODE AND RELATIVE HYBRID CODE
Next Patent: DIRECTIONAL GAMMA RADIATION DETECTOR SYSTEM
Next Patent: DIRECTIONAL GAMMA RADIATION DETECTOR SYSTEM