Title:
SURFACE ANESTHETIC
Document Type and Number:
WIPO Patent Application WO/2020/045581
Kind Code:
A1
Abstract:
[Problem] To provide a surface anesthetic having a high pain relief effect. [Solution] A surface anesthetic comprising lidocaine, isopropyl alcohol and geraniol, wherein geraniol is contained in an amount of 0.000001 to 2% by mass in the surface anesthetic.
Inventors:
HARADA KOJI (JP)
FERDOUS TARANNUM (JP)
GOTO MASAHIRO (JP)
TAHARA YOSHIRO (JP)
FERDOUS TARANNUM (JP)
GOTO MASAHIRO (JP)
TAHARA YOSHIRO (JP)
Application Number:
PCT/JP2019/033959
Publication Date:
March 05, 2020
Filing Date:
August 29, 2019
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K31/045; A61K31/167; A61K47/10; A61P23/00; A61P23/02; A61P43/00
Foreign References:
| JP2001512415A | 2001-08-21 |
Other References:
NORTIER, Y. L. M. ET AL.: "Preparation and stability testing of a hydrogel for topical analgesia", PHARMACY WORLD & SCIENCE, vol. 17, no. 6, 1995, pages 214 - 217, XP000951695, ISSN: 0928-1231, DOI: 10.1007/BF01870614
CASTRO, E. ET AL.: "A comparison of transdermal over-the-counter lidocaine 3.6% menthol 1.25%, Rx lidocaine 5% and placebo for back pain and arthritis", PAIN MANAGEMENT, vol. 7, no. 6, 14 August 2017 (2017-08-14) - November 2017 (2017-11-01), pages 489 - 498, ISSN: 1758-1869
SONG, Y.H. ET AL.: "The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches", DRUG DELIVERY, vol. 16, no. 2, 2009, pages 75 - 81, XP055697201, ISSN: 1071-7544
LIU, Y. ET AL.: "Menthol facilitates the skin analgesic effect of tetracaine gel", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 305, 2005, pages 31 - 36, XP005135512, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2005.08.005
GODWIN, D. A. ET AL.: "Influence of Drug Lipophilicity on Terpenes as Transdermal Penetration Enhancers", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 25, no. 8, 26 July 1999 (1999-07-26), pages 905 - 915, XP055697204, ISSN: 0363-9045
CASTRO, E. ET AL.: "A comparison of transdermal over-the-counter lidocaine 3.6% menthol 1.25%, Rx lidocaine 5% and placebo for back pain and arthritis", PAIN MANAGEMENT, vol. 7, no. 6, 14 August 2017 (2017-08-14) - November 2017 (2017-11-01), pages 489 - 498, ISSN: 1758-1869
SONG, Y.H. ET AL.: "The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches", DRUG DELIVERY, vol. 16, no. 2, 2009, pages 75 - 81, XP055697201, ISSN: 1071-7544
LIU, Y. ET AL.: "Menthol facilitates the skin analgesic effect of tetracaine gel", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 305, 2005, pages 31 - 36, XP005135512, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm.2005.08.005
GODWIN, D. A. ET AL.: "Influence of Drug Lipophilicity on Terpenes as Transdermal Penetration Enhancers", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 25, no. 8, 26 July 1999 (1999-07-26), pages 905 - 915, XP055697204, ISSN: 0363-9045
Attorney, Agent or Firm:
TAKATSU Kazuya (JP)
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