Title:
SURFACE ANTIGEN PROTEIN OF BABESIA PROTOZOA, METHOD FOR DETECTING ANTIBODY AGAINST BABESIA PROTOZOA, AND DIAGNOSTIC METHOD FOR BABESIOSIS
Document Type and Number:
WIPO Patent Application WO/2020/174690
Kind Code:
A1
Abstract:
The present invention provides: a protein obtained by removing, from the amino acid sequence of the full-length surface antigen protein of a Babesia protozoa, the amino acid sequence of the N-terminal signal peptide thereof and the amino acid sequence of the region from a transmembrane region to the C-terminus thereof; and a detection or diagnostic method for Babesiosis using the protein.
More Like This:
Inventors:
KUSAKABE TAKAHIRO (JP)
ARAKAWA TAKESHI (JP)
TAMAKI YUKIHIRO (JP)
TSUJI NAOTOSHI (JP)
ARAKAWA TAKESHI (JP)
TAMAKI YUKIHIRO (JP)
TSUJI NAOTOSHI (JP)
Application Number:
PCT/JP2019/008255
Publication Date:
September 03, 2020
Filing Date:
February 25, 2019
Export Citation:
Assignee:
KAICO LTD (JP)
International Classes:
A61K39/018; C07K14/44; A61P33/02; C12N5/07; C12N15/63; G01N33/53
Foreign References:
| JP2007527707A | 2007-10-04 |
Other References:
ABOGE, G. O. ET AL.: "Molecular characterization and expression of a 47-kDa merozoite surface protein of Babesia gibsoni for serodiagnosis by enzyme-linked immunosorbent assay", J. PROTOZOOL. RES., vol. 20, no. 1, 2010, pages 59 - 69, XP055735473
VERDIDA, R. A. ET AL.: "Serodiagnosis of Babesia gibsoni Infection in Dogs by an Improved Enzyme-Linked Immunosorbent Assay with Recombinant Truncated P50", JOURNAL OF VETERINARY MEDICAL SCIENCE, vol. 66, no. 12, 2004, pages 1517 - 1521, XP055735518
ZHOU, J. ET AL.: "Characterization of the Babesia gibsoni P18 as a homologue of thrombospondin related adhesive protein", MOLECULAR & BIOCHEMICAL PARASITOLOGY, vol. 148, 2006, pages 190 - 198, XP025032710, DOI: 10.1016/j.molbiopara.2006.03.015
DATABASE UniProt [online] 7 November 2018 (2018-11-07), Database accession no. A0A221SSH4
DATABASE UniProt [online] 5 December 2018 (2018-12-05), Database accession no. L0BIN1
IRWIN PETER J: "Canine babesiosis: from molecular taxonomy to control", PARASITES & VECTORS, vol. 2, no. Sppl 1, pages 1 - 9, XP021052883, ISSN: 1756-3305, DOI: 10.1186/1756-3305-2-S1-S4
VERDIDA, R. A. ET AL.: "Serodiagnosis of Babesia gibsoni Infection in Dogs by an Improved Enzyme-Linked Immunosorbent Assay with Recombinant Truncated P50", JOURNAL OF VETERINARY MEDICAL SCIENCE, vol. 66, no. 12, 2004, pages 1517 - 1521, XP055735518
ZHOU, J. ET AL.: "Characterization of the Babesia gibsoni P18 as a homologue of thrombospondin related adhesive protein", MOLECULAR & BIOCHEMICAL PARASITOLOGY, vol. 148, 2006, pages 190 - 198, XP025032710, DOI: 10.1016/j.molbiopara.2006.03.015
DATABASE UniProt [online] 7 November 2018 (2018-11-07), Database accession no. A0A221SSH4
DATABASE UniProt [online] 5 December 2018 (2018-12-05), Database accession no. L0BIN1
IRWIN PETER J: "Canine babesiosis: from molecular taxonomy to control", PARASITES & VECTORS, vol. 2, no. Sppl 1, pages 1 - 9, XP021052883, ISSN: 1756-3305, DOI: 10.1186/1756-3305-2-S1-S4
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Download PDF: