SURFACE CHEMICAL MODIFICATION OF OPTICAL ELEMENTS

WIPO Patent Application WO2002056018

A8

The invention relates to a device suitable for the investigation of ligand-receptor interactions, in particular for the investigation of an analyte target interaction such as biological and chemical molecules and organic components and their interaction with surfaces, consisting of an attenuated total internal reflection element, transparent in the infra-red and of which at least one surface is chemically activated and covalently grafted with an organic molecule able to immobilize the receptor. The invention further relates to the use of said device and a method for the construction of said device comprising the steps of: surface activation of at least one surface of an attenuated total internal reflection element; surface grafting with an organic molecule of the activa ted surface obtained in the previous step; and coupling a receptor via covalent fixation on the organic molecule.

MARCHAND-BRYNAERT JACQUELINE A (BE)
GOORMAGHTIGH ERIK ROBERT MARCE (BE)
HOMBLE FABRICE ROLAND (BE)
VOUE MICHEL PIERRE ERNEST (BE)
DE CONINCK JOEL JOSEPH FLORENT (BE)

PCT/EP2002/000334

August 08, 2002

January 15, 2002

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UNIV CATHOLIQUE LOUVAIN (BE)
UNIV BRUXELLES (BE)
UNIV MONS HAINAUT (BE)
MARCHAND-BRYNAERT JACQUELINE A (BE)
GOORMAGHTIGH ERIK ROBERT MARCE (BE)
HOMBLE FABRICE ROLAND (BE)
VOUE MICHEL PIERRE ERNEST (BE)
DE CONINCK JOEL JOSEPH FLORENT (BE)

G01N21/55; G01N33/543; (IPC1-7): G01N33/543; G01N21/55

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