Title:
SURFACE-MODIFIED IRON OXIDE PARTICLES FOR CANCER CAUTERIZATION
Document Type and Number:
WIPO Patent Application WO/2014/042142
Kind Code:
A1
Abstract:
The problem of the present invention is to provide surface-modified ferromagnetic iron oxide particles that have excellent heat generation properties, excellent dispersion stability in a medium for injection, and that are suitable for electromagnetic induction cancer cauterization. As the solution to this problem, these surface-modified iron oxide particles for cancer cauterization are characterized in that a block copolymer, of polyethylene glycol and polystyrene having phosphorus acid groups in the side chains thereof, is bound to the surface of ferromagnetic iron oxide particles that have a tabular shape wherein the major axis is 20 to 200 nm and the ratio of the major axis to thickness is 1.5 to 30, and that have magnetic properties wherein the coercive force is 30 to 300 Oe, the saturation magnetization is 20 to 80 emu/g, and the squareness ratio of the magnetic hysteresis curve is 0.20 to 0.50.
Inventors:
ODA TATSUYA (JP)
NAGASAKI YUKIO (JP)
ASAI KEI (JP)
KITA EIJI (JP)
YANAGIHARA HIDETO (JP)
OHKOHCHI NOBUHIRO (JP)
KISHIMOTO MIKIO (JP)
NAGASAKI YUKIO (JP)
ASAI KEI (JP)
KITA EIJI (JP)
YANAGIHARA HIDETO (JP)
OHKOHCHI NOBUHIRO (JP)
KISHIMOTO MIKIO (JP)
Application Number:
PCT/JP2013/074350
Publication Date:
March 20, 2014
Filing Date:
September 10, 2013
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
International Classes:
A61K33/26; A61K9/10; A61K9/16; A61K47/32; C01G49/00; C01G49/06; A61N1/40; A61N2/00; A61N5/02
Foreign References:
| JP2010089991A | 2010-04-22 |
Other References:
K.UJIIE ET AL.: "Colloids and Surfaces B:", BIOINTERFACES, vol. 88, 2011, pages 771 - 778, XP028296220
M.KISHIMOTO ET AL., JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol. 324, 2012, pages 1285 - 1289, XP028122998
M. KISHIMOTO ET AL., JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol. 324, 2012, pages 1285 - 1289
K. UJ IIE ET AL., COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 88, 2011, pages 771 - 778
E. KITA ET AL., J. PHYS. D., vol. 43, 2010, pages 474011
E. KITA ET AL.: "SLP: specific loss power", J. APPL. PHYS., vol. 107, 2010, pages 09B321
UJ IIE ET AL., PEG-B-PVBP
See also references of EP 2896398A4
M.KISHIMOTO ET AL., JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol. 324, 2012, pages 1285 - 1289, XP028122998
M. KISHIMOTO ET AL., JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol. 324, 2012, pages 1285 - 1289
K. UJ IIE ET AL., COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 88, 2011, pages 771 - 778
E. KITA ET AL., J. PHYS. D., vol. 43, 2010, pages 474011
E. KITA ET AL.: "SLP: specific loss power", J. APPL. PHYS., vol. 107, 2010, pages 09B321
UJ IIE ET AL., PEG-B-PVBP
See also references of EP 2896398A4
Attorney, Agent or Firm:
TSUJITA Takashi et al. (JP)
Yukifumi Tsujita (JP)
Yukifumi Tsujita (JP)
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