Title:
SURFACE-MODIFIED NANODIAMOND
Document Type and Number:
WIPO Patent Application WO/2023/223962
Kind Code:
A1
Abstract:
Provided is a surface-modified nanodiamond that can selectively accumulate a sufficient amount of boron atoms in cancer tissues or cancer cells and can efficiently kill or injure cancer cells. The surface-modified nanodiamond of the present disclosure comprises a nanodiamond particle and, as surface-modifying groups of the nanodiamond particle, a group containing a boron cluster and a group capable of recognizing a caner cell.
Inventors:
NISHIKAWA MASAHIRO (JP)
KOMATSU NAOKI (JP)
KOMATSU NAOKI (JP)
Application Number:
PCT/JP2023/017906
Publication Date:
November 23, 2023
Filing Date:
May 12, 2023
Export Citation:
Assignee:
UNIV KYOTO (JP)
DAICEL CORP (JP)
DAICEL CORP (JP)
International Classes:
A61K33/22; A61K9/14; A61K41/00; A61K47/04; A61K47/60; A61K47/64; A61K47/69; A61P35/00; C01B32/28; C08G65/06
Domestic Patent References:
| WO2022260136A1 | 2022-12-15 |
Foreign References:
| JP2015147733A | 2015-08-20 |
Other References:
NISHIKAWA MASAHIRO, KANG HEON GYU, ZOU YAJUAN, TAKEUCHI HIDEKAZU, MATSUNO NAOYOSHI, SUZUKI MINORU, KOMATSU NAOKI: "Conjugation of Phenylboronic Acid Moiety through Multistep Organic Transformations on Nanodiamond Surface for an Anticancer Nanodrug for Boron Neutron Capture Therapy", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN,NIPPON KAGAKUKAI, JP, vol. 94, no. 9, 15 September 2021 (2021-09-15), JP , pages 2302 - 2312, XP093109433, ISSN: 0009-2673, DOI: 10.1246/bcsj.20210200
SUMITANI SHOGO, NAGASAKI YUKIO: "Boron neutron capture therapy assisted by boron-conjugated nanoparticles", POLYMER JOURNAL, NATURE PUBLISHING GROUP UK, LONDON, vol. 44, no. 6, 1 June 2012 (2012-06-01), London , pages 522 - 530, XP093109434, ISSN: 0032-3896, DOI: 10.1038/pj.2012.30
LI ZHAO, XU YONG-HONG, AKASAKA TSUKASA, ABE SHIGEAKI, KOMATSU NAOKI, WATARI FUMIO, CHEN XIAO: "Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 20, 1 July 2014 (2014-07-01), AMSTERDAM, NL , pages 5393 - 5406, XP055639280, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.03.041
SUMITANI SHOGO, NAGASAKI YUKIO: "Boron neutron capture therapy assisted by boron-conjugated nanoparticles", POLYMER JOURNAL, NATURE PUBLISHING GROUP UK, LONDON, vol. 44, no. 6, 1 June 2012 (2012-06-01), London , pages 522 - 530, XP093109434, ISSN: 0032-3896, DOI: 10.1038/pj.2012.30
LI ZHAO, XU YONG-HONG, AKASAKA TSUKASA, ABE SHIGEAKI, KOMATSU NAOKI, WATARI FUMIO, CHEN XIAO: "Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 20, 1 July 2014 (2014-07-01), AMSTERDAM, NL , pages 5393 - 5406, XP055639280, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.03.041
Attorney, Agent or Firm:
G-CHEMICAL INTELLECTUAL PROPERTY FIRM (JP)
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