SURFACTANT COMPOUNDS AND USES THEREOF

WIPO Patent Application WO/2003/013610

A2

A pharmaceutical aerosol formulation comprising a particulate medicament, one or more fluorocarbon or hydrogen-containing fluorocarbon propellants and a compound of the general formula (I) or a salt or solvate thereof, wherein A represents a straight chain C¿1?-¿16? alkylene substituted by n groups of formula B; n represents an integer 1 to 3; and B independently represents C¿1?-¿4? fluoroalkylC¿0?-¿6? alkylene-, C¿1?-¿4? fluoroalkylC¿0?-¿6? alkylene-O-, or C¿1?-¿4? alkylC¿0?-¿6? alkylene-O- wherein at least one substituent of formula B contains at least one fluorine atom and each C¿1?-¿4? fluoroalkyl- moiety contains one or more fluorine atoms but not more than 3 consecutive perfluorinated carbon atoms. The invention also extends to uses of compounds of formula (I) and certain novel compounds within the definition of formula (I).

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KALDOR ISTVAN (US)
LOOKER BRIAN EDGAR (GB)
LUNNISS CHRISTOPHER JAMES (GB)
REDGRAVE ALISON JUDITH (GB)

PCT/GB2002/003586

February 20, 2003

August 02, 2002

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GLAXO GROUP LTD (GB)
KALDOR ISTVAN (US)
LOOKER BRIAN EDGAR (GB)
LUNNISS CHRISTOPHER JAMES (GB)
REDGRAVE ALISON JUDITH (GB)

A61K9/00; A61K9/12; A61K31/137; A61K31/20; A61K31/56; A61K47/00; A61K47/06; A61K47/12; C07B61/00; C07C27/02; C07C51/09; C07C51/363; C07C53/21; C07C57/02; C07C59/135; C07C69/63; C07C69/708; C09K3/30; (IPC1-7): A61K47/00

WO1992000107A1	1992-01-09
WO1991014422A1	1991-10-03

EP0021739A1	1981-01-07
US3498923A	1970-03-03
FR2613357A1	1988-10-07

MULLER, N. ET AL.: "Investigation of micelle structure by fluorine magnetic resonance. I. Sodium 10,10,10-trifluorocaprate and related compounds" J. PHYS. CHEM., vol. 71, no. 4, March 1967 (1967-03), pages 957-962, XP002230279
GAVLIN, G. ET AL.: "The synthesis of omega-trifluorostearic acid and omega-trifluoro-n-octadecyl amine" J. ORG. CHEM., vol. 21, December 1956 (1956-12), pages 1342-1347, XP002230280
PARK, J.D. ET AL.: "Applicability of the Arndt-Eistert reaction to fluorinated acids and their derivatives" J. ORG. CHEM., vol. 23, August 1958 (1958-08), pages 1166-1169, XP002230281
BRACE, N.O.: "Long chain alkanoic and alkenoic acids with perfluoroalkyl terminal segments" J. ORG. CHEM., vol. 27, December 1962 (1962-12), pages 4491-4498, XP001122366 cited in the application
GU, C. ET AL.: "Dissociative and reactive hyperthermal ion-surface collisions..." J. AM. CHEM. SOC., vol. 121, 1999, pages 10554-10562, XP001135063 cited in the application
GRAUPE, M. ET AL.: "Terminally perfluorinated long-chain alkanethiols" J. FLUORINE CHEM., vol. 93, no. 2, 4 February 1999 (1999-02-04), pages 107-115, XP004156221 cited in the application

Thornley, Rachel M. (980 Great West Road Brentford, Middlesex TW8 9GS, GB)
Giddings, Peter John (Corporate Intellectual Property_ 980 Great West Roa, Brentford Middlesex TW8 9GS, GB)

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