Title:
SURFACTANT COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003013610
Kind Code:
A3
Abstract:
A pharmaceutical aerosol formulation comprising a particulate medicament, one or more fluorocarbon or hydrogen-containing fluorocarbon propellants and a compound of the general formula (I) or a salt or solvate thereof, wherein A represents a straight chain C1-16 alkylene substituted by n groups of formula B; n represents an integer 1 to 3; and B independently represents C1-4 fluoroalkylC0-6 alkylene-, C1-4 fluoroalkylC0-6 alkylene-O-, or C1-4 alkylC0-6 alkylene-O- wherein at least one substituent of formula B contains at least one fluorine atom and each C1-4 fluoroalkyl- moiety contains one or more fluorine atoms but not more than 3 consecutive perfluorinated carbon atoms. The invention also extends to uses of compounds of formula (I) and certain novel compounds within the definition of formula (I).
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Inventors:
KALDOR ISTVAN (US)
LOOKER BRIAN EDGAR (GB)
LUNNISS CHRISTOPHER JAMES (GB)
REDGRAVE ALISON JUDITH (GB)
LOOKER BRIAN EDGAR (GB)
LUNNISS CHRISTOPHER JAMES (GB)
REDGRAVE ALISON JUDITH (GB)
Application Number:
PCT/GB2002/003586
Publication Date:
October 30, 2003
Filing Date:
August 02, 2002
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
KALDOR ISTVAN (US)
LOOKER BRIAN EDGAR (GB)
LUNNISS CHRISTOPHER JAMES (GB)
REDGRAVE ALISON JUDITH (GB)
KALDOR ISTVAN (US)
LOOKER BRIAN EDGAR (GB)
LUNNISS CHRISTOPHER JAMES (GB)
REDGRAVE ALISON JUDITH (GB)
International Classes:
A61K9/00; A61K31/137; A61K31/20; A61K31/56; A61K47/00; A61K47/06; A61K9/12; A61K47/12; C07B61/00; C07C27/02; C07C51/09; C07C51/363; C07C53/21; C07C57/02; C07C59/135; C07C69/63; C07C69/708; C09K3/30; (IPC1-7): A61K9/12; C09K3/30; A61K47/12; C07C53/21; A61K31/56; A61K31/137
Domestic Patent References:
WO1992000107A1 | 1992-01-09 | |||
WO1991014422A1 | 1991-10-03 |
Foreign References:
EP0021739A1 | 1981-01-07 | |||
US3498923A | 1970-03-03 | |||
FR2613357A1 | 1988-10-07 |
Other References:
MULLER, N. ET AL.: "Investigation of micelle structure by fluorine magnetic resonance. I. Sodium 10,10,10-trifluorocaprate and related compounds", J. PHYS. CHEM., vol. 71, no. 4, March 1967 (1967-03-01), pages 957 - 962, XP002230279
GAVLIN, G. ET AL.: "The synthesis of omega-trifluorostearic acid and omega-trifluoro-n-octadecyl amine", J. ORG. CHEM., vol. 21, December 1956 (1956-12-01), pages 1342 - 1347, XP002230280
PARK, J.D. ET AL.: "Applicability of the Arndt-Eistert reaction to fluorinated acids and their derivatives", J. ORG. CHEM., vol. 23, August 1958 (1958-08-01), pages 1166 - 1169, XP002230281
BRACE, N.O.: "Long chain alkanoic and alkenoic acids with perfluoroalkyl terminal segments", J. ORG. CHEM., vol. 27, December 1962 (1962-12-01), pages 4491 - 4498, XP001122366
GU, C. ET AL.: "Dissociative and reactive hyperthermal ion-surface collisions...", J. AM. CHEM. SOC., vol. 121, 1999, pages 10554 - 10562, XP001135063
GRAUPE, M. ET AL.: "Terminally perfluorinated long-chain alkanethiols", J. FLUORINE CHEM., vol. 93, no. 2, 4 February 1999 (1999-02-04), pages 107 - 115, XP004156221
GAVLIN, G. ET AL.: "The synthesis of omega-trifluorostearic acid and omega-trifluoro-n-octadecyl amine", J. ORG. CHEM., vol. 21, December 1956 (1956-12-01), pages 1342 - 1347, XP002230280
PARK, J.D. ET AL.: "Applicability of the Arndt-Eistert reaction to fluorinated acids and their derivatives", J. ORG. CHEM., vol. 23, August 1958 (1958-08-01), pages 1166 - 1169, XP002230281
BRACE, N.O.: "Long chain alkanoic and alkenoic acids with perfluoroalkyl terminal segments", J. ORG. CHEM., vol. 27, December 1962 (1962-12-01), pages 4491 - 4498, XP001122366
GU, C. ET AL.: "Dissociative and reactive hyperthermal ion-surface collisions...", J. AM. CHEM. SOC., vol. 121, 1999, pages 10554 - 10562, XP001135063
GRAUPE, M. ET AL.: "Terminally perfluorinated long-chain alkanethiols", J. FLUORINE CHEM., vol. 93, no. 2, 4 February 1999 (1999-02-04), pages 107 - 115, XP004156221
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