Title:
SURGICAL BARRIER POSSESSING CLINICALLY IMPORTANT ABSORPTION CHARACTERISTICS
Document Type and Number:
WIPO Patent Application WO/2013/043998
Kind Code:
A3
Abstract:
The present disclosure provides copolymers useful in medical devices. For example, the disclosure provides copolymers comprising the polymerization product ester block, ether blocks and diisocyanates. In certain embodiments, the disclosure provides a medical copolymer for implantation comprising ester blocks and ether blocks, wherein: the ester blocks comprise a negative free energy transfer and the ether blocks comprise a positive free energy transfer, the ether and ester blocks are less than 1/10 the length of said copolymer, and, the blocks are distributed such that no domain of contiguous blocks possessing the same polarity of free energy transfer are less than 1/3 of the molecular weight of the copolymer. The disclosure further provides methods of making the aforementioned polymers, and medical devices comprising the polymers.
Inventors:
WIESE HINRICH (DE)
TESSMAR JOERG (DE)
KESSLER MARTINA (DE)
BLUECHER LUKAS (DE)
MILBOCKER MICHAEL (US)
TESSMAR JOERG (DE)
KESSLER MARTINA (DE)
BLUECHER LUKAS (DE)
MILBOCKER MICHAEL (US)
Application Number:
PCT/US2012/056523
Publication Date:
December 12, 2013
Filing Date:
September 21, 2012
Export Citation:
Assignee:
BVW HOLDING AG (CH)
WIESE HINRICH (DE)
TESSMAR JOERG (DE)
KESSLER MARTINA (DE)
BLUECHER LUKAS (DE)
MILBOCKER MICHAEL (US)
WIESE HINRICH (DE)
TESSMAR JOERG (DE)
KESSLER MARTINA (DE)
BLUECHER LUKAS (DE)
MILBOCKER MICHAEL (US)
International Classes:
A61L31/06; A61K31/765; A61K31/77; A61L31/14; C08G18/40; C08G18/42; C08G18/48; C08G63/06; C08G63/66; C08G65/26
Domestic Patent References:
| WO1998002171A1 | 1998-01-22 | |||
| WO1999002168A1 | 1999-01-21 |
Other References:
GORNA K ET AL: "In vitro degradation of novel medical biodegradable aliphatic polyurethanes based on epsilon-caprolactone and Pluronics(R) with various hydrophilicities", POLYMER DEGRADATION AND STABILITY, BARKING, GB, vol. 75, no. 1, 1 January 2002 (2002-01-01), pages 113 - 122, XP004326581, ISSN: 0141-3910, DOI: 10.1016/S0141-3910(01)00210-5
LOH ET AL: "Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol)", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 28, no. 28, 14 July 2007 (2007-07-14), pages 4113 - 4123, XP022153631, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2007.05.016
SOSNIK A ET AL: "Reverse thermo-responsive poly(ethylene oxide) and poly(propylene oxide) multiblock copolymers", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 4, 1 February 2005 (2005-02-01), pages 349 - 357, XP025280896, ISSN: 0142-9612, [retrieved on 20050201], DOI: 10.1016/J.BIOMATERIALS.2004.02.041
LOH ET AL: "Hydrolytic degradation and protein release studies of thermogelling polyurethane copolymers consisting of poly[(R)-3-hydroxybutyrate], poly(ethylene glycol), and poly(propylene glycol)", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 28, no. 28, 14 July 2007 (2007-07-14), pages 4113 - 4123, XP022153631, ISSN: 0142-9612, DOI: 10.1016/J.BIOMATERIALS.2007.05.016
SOSNIK A ET AL: "Reverse thermo-responsive poly(ethylene oxide) and poly(propylene oxide) multiblock copolymers", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 4, 1 February 2005 (2005-02-01), pages 349 - 357, XP025280896, ISSN: 0142-9612, [retrieved on 20050201], DOI: 10.1016/J.BIOMATERIALS.2004.02.041
Attorney, Agent or Firm:
LANG, Hilary D. (Roundabout Plaza1600 Division St., Suite 50, Nashville Tennessee, US)
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